Low-Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events.


Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 24 11 2020
medline: 27 3 2021
entrez: 23 11 2020
Statut: ppublish

Résumé

Background Conventional "low-density lipoprotein cholesterol (LDL-C)" assays measure cholesterol content in both low-density lipoprotein and lipoprotein(a) particles. To clarify the consequences of this methodological limitation for clinical care, our study aimed to compare associations of "LDL-C" and corrected LDL-C with risk of cardiovascular disease and to assess the impact of this correction on the classification of patients into guideline-recommended LDL-C categories. Methods and Results Lipoprotein(a) cholesterol content was estimated as 30% of lipoprotein(a) mass and subtracted from "LDL-C" to obtain corrected LDL-C values (LDL-C

Identifiants

pubmed: 33222611
doi: 10.1161/JAHA.119.016318
pmc: PMC7763787
doi:

Substances chimiques

Cholesterol, LDL 0
Lipoprotein(a) 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e016318

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Auteurs

Peter Willeit (P)

Department of Neurology Medical University of Innsbruck Innsbruck Austria.
Department of Public Health and Primary Care University of Cambridge Cambridge UK.

Calvin Yeang (C)

Division of Cardiovascular Medicine Sulpizio Cardiovascular Center University of California, San Diego La Jolla CA.

Patrick M Moriarty (PM)

Division of Clinical Pharmacology Department of Internal Medicine University of Kansas Medical Center Kansas City MO.

Lena Tschiderer (L)

Department of Neurology Medical University of Innsbruck Innsbruck Austria.

Stephen A Varvel (SA)

Salveo Diagnostics, Inc Richmond VA.

Joseph P McConnell (JP)

Salveo Diagnostics, Inc Richmond VA.

Sotirios Tsimikas (S)

Division of Cardiovascular Medicine Sulpizio Cardiovascular Center University of California, San Diego La Jolla CA.

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Classifications MeSH