A case-control study to evaluate the impact of the breast screening programme on mortality in England.
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
18
03
2020
accepted:
28
10
2020
revised:
21
10
2020
pubmed:
24
11
2020
medline:
15
7
2021
entrez:
23
11
2020
Statut:
ppublish
Résumé
Over the past 30 years since the implementation of the National Health Service Breast Screening Programme, improvements in diagnostic techniques and treatments have led to the need for an up-to-date evaluation of its benefit on risk of death from breast cancer. An initial pilot case-control study in London indicated that attending mammography screening led to a mortality reduction of 39%. Based on the same study protocol, an England-wide study was set up. Women aged 47-89 years who died of primary breast cancer in 2010 or 2011 were selected as cases (8288 cases). When possible, two controls were selected per case (15,202 controls) and were matched by date of birth and screening area. Conditional logistic regressions showed a 38% reduction in breast cancer mortality after correcting for self-selection bias (OR 0.62, 95% CI 0.56-0.69) for women being screened at least once. Secondary analyses by age group, and time between last screen and breast cancer diagnosis were also performed. According to this England-wide case-control study, mammography screening still plays an important role in lowering the risk of dying from breast cancer. Women aged 65 or over see a stronger and longer lasting benefit of screening compared to younger women.
Sections du résumé
BACKGROUND
Over the past 30 years since the implementation of the National Health Service Breast Screening Programme, improvements in diagnostic techniques and treatments have led to the need for an up-to-date evaluation of its benefit on risk of death from breast cancer. An initial pilot case-control study in London indicated that attending mammography screening led to a mortality reduction of 39%.
METHODS
Based on the same study protocol, an England-wide study was set up. Women aged 47-89 years who died of primary breast cancer in 2010 or 2011 were selected as cases (8288 cases). When possible, two controls were selected per case (15,202 controls) and were matched by date of birth and screening area.
RESULTS
Conditional logistic regressions showed a 38% reduction in breast cancer mortality after correcting for self-selection bias (OR 0.62, 95% CI 0.56-0.69) for women being screened at least once. Secondary analyses by age group, and time between last screen and breast cancer diagnosis were also performed.
CONCLUSIONS
According to this England-wide case-control study, mammography screening still plays an important role in lowering the risk of dying from breast cancer. Women aged 65 or over see a stronger and longer lasting benefit of screening compared to younger women.
Identifiants
pubmed: 33223536
doi: 10.1038/s41416-020-01163-2
pii: 10.1038/s41416-020-01163-2
pmc: PMC7884709
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
736-743Références
Forrest, A. P. M. Breast cancer screening: report to the Health Ministers of England, Wales, Scotland and Northern Ireland by a working group. (HM Stationery Office, London, 1987)
Moser, K., Sellars, S., Wheaton, M., Cooke, J., Duncan, A., Maxwell, A. et al. Extending the age range for breast screening in England: pilot study to assess the feasibility and acceptability of randomization. J. Med. Screen 18, 96–102 (2011).
doi: 10.1258/jms.2011.011065
Plevritis, S. K., Munoz, D., Kurian, A. W., Stout, N. K., Alagoz, O., Near, A. M. et al. Association of screening and treatment with breast cancer mortality by molecular subtype in US Women, 2000-2012. Jama 319, 154–164 (2018).
doi: 10.1001/jama.2017.19130
Patnick, J. NHS breast screening: the progression from one to two views. J. Med Screen 11, 55–56 (2004).
doi: 10.1258/096914104774061001
Cancer Research UK. Breast cancer survival trends over time. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer/survival#heading-Two (2014).
Cancer Research UK. Cancer incidence for common cancers. https://www.cancerresearchuk.org/health-professional/cancer-statistics/incidence/common-cancers-compared#heading-Two (2020).
Cancer Research UK. Cancer mortality for common cancers. https://www.cancerresearchuk.org/health-professional/cancer-statistics/mortality/common-cancers-compared#heading-Two (2019).
Sasieni, P., Adams, J. & Cuzick, J. Benefit of cervical screening at different ages: evidence from the UK audit of screening histories. Br. J. Cancer 89, 88–93 (2003).
doi: 10.1038/sj.bjc.6600974
Massat, N. J., Sasieni, P. D., Parmar, D. & Duffy, S. W. An ongoing case-control study to evaluate the NHS breast screening programme. BMC Cancer 13, 596 (2013).
doi: 10.1186/1471-2407-13-596
Massat, N. J., Dibden, A., Parmar, D., Cuzick, J., Sasieni, P. D. & Duffy, S. W. Impact of screening on breast cancer mortality: The UK Program 20 Years On. Cancer Epidemiol. Biomark. Prev. 25, 455–462 (2016).
doi: 10.1158/1055-9965.EPI-15-0803
Massat, N. J., Sasieni, P. D., Tataru, D., Parmar, D., Cuzick, J. & Duffy, S. W. Explaining the better prognosis of screening-exposed breast cancers: influence of tumor characteristics and treatment. Cancer Epidemiol. Biomark. Prev. 25, 479–487 (2016).
doi: 10.1158/1055-9965.EPI-15-0804
The NHS Information Centre. Breast Screening Programme, England 2010-11. https://files.digital.nhs.uk/publicationimport/pub05xxx/pub05244/bres-scre-prog-eng-2010-11-rep.pdf (2012).
Department of Health. Information Governance Toolkit. https://www.igt.hscic.gov.uk (2020).
StataCorp. Stata Statistical Software: Release 13. (College Station, 2013).
Duffy, S. W., Cuzick, J., Tabar, L., Vitak, B., Chen, T. H.-H., Yen, M.-F. et al. Correcting for non-compliance bias in case–control studies to evaluate cancer screening programmes. J. R. Stat. Soc. Ser. C. 51, 235–243 (2002).
doi: 10.1111/1467-9876.00266
Johns, L. E., Coleman, D. A., Swerdlow, A. J. & Moss, S. M. Effect of population breast screening on breast cancer mortality to 2005 in England and Wales: an individidual-level cohort study. Br. J. Cancer 116, 246–252 (2017).
doi: 10.1038/bjc.2016.415
Independent, U. K. Panel on Breast Cancer Screening. The benefits and harms of breast cancer screening: an independent review. Lancet 380, 1778–1786 (2012).
doi: 10.1016/S0140-6736(12)61611-0
Gøtzsche, P. C., Jørgensen, K. Screening for breast cancer with mammography. Cochrane Database of Syst. Rev. 6, CD001877 (2013).
International Agency for Research on Cancer. Breast Cancer Screening, Vol. 15. (IARC Handbooks of Cancer Prevention, 2016).
Dimitrova, N., Parkinson, Z. S., Bramesfeld, A., Ulutürk, A., Bocchi, G., López-Alcalde, J. et al. European Guidelines for Breast Cancer Screening and Diagnosis–the European Breast Guidelines. Joint Research Centre Technical Reports (Luxembourg Publications Office of the European Union, 2016).
Siu, A. L. Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann. Intern Med. 164, 279–296 (2016).
doi: 10.7326/M15-2886
Duffy, S. W., Chen, T. H.-H., Smith, R. A., Yen, A. M.-F. & Tabar, L. Real and artificial controversies in breast cancer screening. Breast Cancer Manag. 2, 519–528 (2013).
doi: 10.2217/bmt.13.53
Massat, N. J., Douglas, E., Waller, J., Wardle, J. & Duffy, S. W. Variation in cervical and breast cancer screening coverage in England: a cross-sectional analysis to characterise districts with atypical behaviour. BMJ Open 5, e007735 (2015).
doi: 10.1136/bmjopen-2015-007735
Tabar, L., Fagerberg, G., Duffy, S. W., Day, N. E., Gad, A. & Grontoft, O. Update of the Swedish two-county program of mammographic screening for breast cancer. Radio. Clin. North Am. 30, 187–210 (1992).
Eilbert, K. W., Carroll, K., Peach, J., Khatoon, S., Basnett, I. & McCulloch, N. Approaches to improving breast screening uptake: evidence and experience from Tower Hamlets. Br. J. Cancer 101, S64–S67 (2009).
doi: 10.1038/sj.bjc.6605393
Douglas, E., Waller, J., Duffy, S. W. & Wardle, J. Socioeconomic inequalities in breast and cervical screening coverage in England: are we closing the gap? J. Med. Screen 23, 98–103 (2016).
doi: 10.1177/0969141315600192
Walter, S. D. Mammographic screening: case-control studies. Ann. Oncol. 14, 1190–1192 (2003).
doi: 10.1093/annonc/mdg320
Olsen, A. H., Njor, S. H., Vejborg, I., Schwartz, W., Dalgaard, P., Jensen, M.-B. et al. Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study. BMJ 330, 220 (2005).
doi: 10.1136/bmj.38313.639236.82
Benz, C. C. Impact of aging on the biology of breast cancer. Crit. Rev. Oncol. Hematol. 66, 65–74 (2008).
doi: 10.1016/j.critrevonc.2007.09.001
The Independent Breast Screening Review 2018. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/764413/independent-breast-screening-review-report.pdf (2018).
Moss, S. M., Summerley, M. E., Thomas, B. T., Ellman, R. & Chamberlain, J. O. A case-control evaluation of the effect of breast cancer screening in the United Kingdom trial of early detection of breast cancer. J. Epidemiol. Community Health 46, 362–364 (1992).
doi: 10.1136/jech.46.4.362
Allgood, P. C., Warwick, J., Warren, R. M., Day, N. E. & Duffy, S. W. A case-control study of the impact of the East Anglian breast screening programme on breast cancer mortality. Br. J. Cancer 98, 206–209 (2008).
doi: 10.1038/sj.bjc.6604123
van der Waal, D., Broeders, M. J., Verbeek, A. L., Duffy, S. W. & Moss, S. M. Case-control studies on the effectiveness of breast cancer screening: insights from the UK Age Trial. Epidemiology 26, 590–596 (2015).
doi: 10.1097/EDE.0000000000000285
Johns, L. E., Swerdlow, A. J. & Moss, S. M. Effect of population breast screening on breast cancer mortality to 2005 in England and Wales: a nested case-control study within a cohort of one million women. J. Med. Screen 25, 76–81 (2018).
doi: 10.1177/0969141317713232
Sasco, A. J., Day, N. E. & Walter, S. D. Case-control studies for the evaluation of screening. J. Chronic Dis. 39, 399–405 (1986).
doi: 10.1016/0021-9681(86)90126-8