The Effect of Allograft Transplantation of Sertoli Cell on Expression of NF-кB, Bax Proteins, and Ischemic Tolerance in Rats with Focal Cerebral Ischemia.
Apoptosis
Blood-brain barrier
Brain ischemia
Cell transplantation
Edema
Infarction
Inflammation
Journal
Iranian journal of pharmaceutical research : IJPR
ISSN: 1735-0328
Titre abrégé: Iran J Pharm Res
Pays: Netherlands
ID NLM: 101208407
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
23
11
2020
pubmed:
24
11
2020
medline:
24
11
2020
Statut:
ppublish
Résumé
One of the newest methods to reduce cerebral ischemia damages is cell therapy. The aim of this study is to evaluate the effect of Sertoli cell transplantation on ischemia-induced injuries in animal models of stroke. Rats were divided into four groups: transplant+ischemia, ischemia, sham, and control. Sertoli cells were separated from the other testis of rats and cultured. Unilateral Sertoli cell transplantation was performed in the right striatum by using stereotaxic surgery. For induction of brain ischemia, middle cerebral artery occlusion surgery was used 14 days after transplantation. By using western blotting method, expression of nuclear factor kappa (NF-кB) and Bax were evaluated. In this study, a remarkable decrease in neurological deficits, infection, blood-brain barrier permeability, and brain edema was observed in the cell transplant recipient group in comparison with the ischemia group. Probably, a reduction in inflammation (NF-кB factor) and apoptosis (Bax) following injection of Sertoli cells result in amelioration of ischemic damages induced by MCAO surgery.
Identifiants
pubmed: 33224215
doi: 10.22037/ijpr.2020.15574.13189
pmc: PMC7667533
doi:
Types de publication
Journal Article
Langues
eng
Pagination
98-114Références
Trends Neurosci. 1999 Sep;22(9):391-7
pubmed: 10441299
J Thorac Cardiovasc Surg. 2011 Dec;142(6):1540-4
pubmed: 21664623
Cell Mol Neurobiol. 2006 Oct-Nov;26(7-8):1057-83
pubmed: 16710759
J Cereb Blood Flow Metab. 1994 Jan;14(1):70-4
pubmed: 8263060
Stroke. 1998 Jul;29(7):1417-22
pubmed: 9660398
Biol Reprod. 2003 Mar;68(3):996-1002
pubmed: 12604653
J Neurosci. 2012 Jul 11;32(28):9588-600
pubmed: 22787045
Brain Res. 2009 Aug 11;1284:1-11
pubmed: 19520066
Oxid Med Cell Longev. 2013;2013:297357
pubmed: 23691263
J Cereb Blood Flow Metab. 2001 Sep;21(9):1097-104
pubmed: 11524614
J Neurosci. 1997 Jun 1;17(11):4341-8
pubmed: 9151750
Stroke. 2007 Feb;38(2 Suppl):674-6
pubmed: 17261713
Pharmacol Rep. 2007 Jan-Feb;59(1):25-33
pubmed: 17377203
J Cereb Blood Flow Metab. 1990 Mar;10(2):290-3
pubmed: 1689322
Brain Res. 2007 Jun 4;1152:228-33
pubmed: 17475225
Prog Neurobiol. 1998 Jan;54(1):71-85
pubmed: 9460794
Neurol Clin. 2006 Feb;24(1):1-21
pubmed: 16443127
Stroke. 2000 Sep;31(9):2212-7
pubmed: 10978054
EMBO J. 1998 Jul 15;17(14):3878-85
pubmed: 9670005
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1672-6
pubmed: 8127864
Cell Death Differ. 1998 Oct;5(10):911-9
pubmed: 10203697
Exp Neurol. 2005 Dec;196(2):235-43
pubmed: 16242126
Brain Res. 1999 Aug 14;838(1-2):227-33
pubmed: 10446339
J Neurosurg. 2000 Mar;92(3):493-9
pubmed: 10701543
J Lab Clin Med. 1992 Jun;119(6):598-620
pubmed: 1593209
Brain Res Mol Brain Res. 2001 Feb 19;87(1):71-80
pubmed: 11223161
Behav Brain Res. 2019 Jul 23;367:158-165
pubmed: 30905711
Mol Cell Endocrinol. 2011 Feb 10;333(1):85-95
pubmed: 21172404
Cerebrovasc Brain Metab Rev. 1995 Spring;7(1):1-54
pubmed: 7742171
Stroke. 2003 Jun;34(6):1519-25
pubmed: 12730553
Brain. 2005 Jan;128(Pt 1):52-63
pubmed: 15509618
J Mol Neurosci. 2018 Apr;64(4):533-542
pubmed: 29550901
J Appl Physiol (1985). 1994 Jan;76(1):5-13
pubmed: 8175547
Mol Med Today. 1998 Nov;4(11):471-7
pubmed: 9857366
Neuroreport. 2001 Oct 29;12(15):3381-4
pubmed: 11711890
Mol Pharmacol. 1998 Apr;53(4):663-9
pubmed: 9547356
J Reprod Infertil. 2017 Apr-Jun;18(2):213-217
pubmed: 28868245
Nutrition. 1996 Apr;12(4):274-7
pubmed: 8862535
Exp Neurol. 1997 Nov;148(1):388-92
pubmed: 9398481
Neural Regen Res. 2013 Jun 5;8(16):1491-9
pubmed: 25206445
Stroke. 2003 May;34(5):1304-10
pubmed: 12677018
Stroke. 2001 May;32(5):1226-33
pubmed: 11340238
FEBS Lett. 1994 Aug 8;349(3):392-6
pubmed: 8050602
Stroke. 1995 Jul;26(7):1252-7; discussion 1257-8
pubmed: 7541573
J Cereb Blood Flow Metab. 2017 Feb;37(2):456-470
pubmed: 26823471
Stroke. 2005 Dec;36(12):2725-30
pubmed: 16282547
Contraception. 2002 Apr;65(4):305-11
pubmed: 12020784
Development. 2012 Dec 1;139(23):4347-55
pubmed: 23095883
Exp Transl Stroke Med. 2014 Jun 06;6:6
pubmed: 24949193
Stroke. 1998 Oct;29(10):2189-95
pubmed: 9756602
Neurotox Res. 2003;5(6):443-50
pubmed: 14715448
PLoS One. 2007 Jan 17;2(1):e156
pubmed: 17225860
J Biol Chem. 1997 May 2;272(18):12181-8
pubmed: 9115291
Am J Pathol. 1997 Dec;151(6):1775-84
pubmed: 9403728
Cytokine Growth Factor Rev. 2006 Aug;17(4):305-23
pubmed: 16621671
BMC Neurosci. 2008 Dec 10;9:117
pubmed: 19077183
Trends Pharmacol Sci. 1995 Sep;16(9):283-5
pubmed: 7482990
Iran J Neurol. 2015 Jul 6;14(3):158-63
pubmed: 26622981
Brain Res Mol Brain Res. 1999 Aug 25;71(2):210-6
pubmed: 10521575
J Neurosci. 2001 Oct 1;21(19):7724-32
pubmed: 11567062
In Vitro Cell Dev Biol. 1986 Jun;22(6):325-31
pubmed: 2428803
J Am Coll Cardiol. 2015 Jun 23;65(24):2628-2635
pubmed: 26088302
Cell Transplant. 2017 Jul;26(7):1247-1261
pubmed: 28933218
J Invest Surg. 2005 Nov-Dec;18(6):335-50
pubmed: 16319055