German guidelines on the diagnosis and treatment of neurosyphilis.
Journal
Neurological research and practice
ISSN: 2524-3489
Titre abrégé: Neurol Res Pract
Pays: England
ID NLM: 101767802
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
07
2020
accepted:
22
07
2020
entrez:
23
11
2020
pubmed:
24
11
2020
medline:
24
11
2020
Statut:
epublish
Résumé
In view of the importance of neurosyphilis and the difficulties encountered in diagnosing it, the S1 guideline "Neurosyphilis" has been published by the German Society for Neurology (DGN) in accordance with the stipulations of the Association of the Scientific Medical Societies in Germany (AWMF). The present article is an abridged translation of that German guideline. (a) Neurosyphilis can manifest as early neurosyphilis (meningitis, meningovascular neurosyphilis or syphilitic gummas) or late neurosyphilis (tabes dorsalis, general paresis). (b) The following diagnostic criteria help to establish the presence of probable neurosyphilis (always point iv, accompanied by any two of points i to iii): (i) subacute or chronic neuro-psychiatric symptoms; (ii) increased cerebrospinal fluid (CSF) cell count or signs of blood-CSF barrier disruption; (iii) positive effect of anti-neurosyphilis antibiotic therapy on clinical course and CSF findings; (iv) positive TPHA/TPPA or FTA test in serum. (c) The diagnosis of neurosyphilis is confirmed by the subsequent detection of intrathecal production of antibodies against The German guideline on the diagnosis and treatment of neurosyphilis is a practical tool to support clinicians in diagnosing and treating patients with neurosyphilis. This article is an abridged translation of this guideline (Klein MW, J.; Angstwurm, K.; Esser, S.; Hahn, K.; Matschke, M.; Scheithauer, S.; Schoefer, H.; Sturzenegger, M.; Wildemann, B. Neurosyphilis, S1-Leitlinie. Deutsche Gesellschaft für Neurologie, Leitlinien für Diagnostik und Thearpie in der Neurologie 2020).
Identifiants
pubmed: 33225223
doi: 10.1186/s42466-020-00081-1
pii: 81
pmc: PMC7669305
doi:
Types de publication
Journal Article
Langues
eng
Pagination
33Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsNot applicable.
Références
Sex Health. 2018 Jul;15(4):358-360
pubmed: 29706150
Ann Intern Med. 1988 Dec 1;109(11):855-62
pubmed: 3056164
Medicine (Baltimore). 2009 Nov;88(6):331-40
pubmed: 19910747
AIDS. 2008 Jun 19;22(10):1145-51
pubmed: 18525260
Pharmacotherapy. 2010 Apr;30(4):119e-22e
pubmed: 20334461
Springerplus. 2016 Jun 16;5(1):743
pubmed: 27376011
CMAJ. 2017 Jul 24;189(29):E962-E965
pubmed: 28739848
Am J Ophthalmol. 1946 Jan;29:92
pubmed: 21007781
Medicine (Baltimore). 2018 Mar;97(9):e0078
pubmed: 29489672
Clin Infect Dis. 2016 Nov 1;63(9):1180-1186
pubmed: 27585981
Sex Transm Infect. 2018 Aug;94(5):337-339
pubmed: 28196838
J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):300-7
pubmed: 21948891
Medicine (Baltimore). 2018 Nov;97(45):e13171
pubmed: 30407349
Neuroradiology. 2013 Mar;55(4):379-88
pubmed: 23274762
J Eur Acad Dermatol Venereol. 2014 Dec;28(12):1581-93
pubmed: 25348878
J Infect Chemother. 2019 May;25(5):362-364
pubmed: 30538059
Clin Microbiol Infect. 2018 Dec;24(12):1234-1240
pubmed: 29674128
Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):125-134
pubmed: 30368740
Am J Clin Pathol. 2015 Apr;143(4):479-84
pubmed: 25779998
Sex Transm Dis. 2010 May;37(5):283-7
pubmed: 20393380
J Dtsch Dermatol Ges. 2015 May;13(5):472-80
pubmed: 25918100
Neurosurgery. 2009 Mar;64(3):568-75; discussioin 575-6
pubmed: 19240620
Int J Dermatol. 2014 Jul;53(7):812-9
pubmed: 24261864
Neurol Sci. 2018 Jan;39(1):185-187
pubmed: 28914386
Sex Transm Dis. 2012 Jun;39(6):453-7
pubmed: 22592831
Sex Transm Dis. 2019 Jan;46(1):37-40
pubmed: 30044338
Sex Transm Dis. 2001 Mar;28(3):158-65
pubmed: 11289198
Fluids Barriers CNS. 2015 May 15;12:12
pubmed: 25975424
Biomed Res Int. 2019 May 6;2019:2426313
pubmed: 31198783
MMWR Recomm Rep. 2010 Dec 17;59(RR-12):1-110
pubmed: 21160459
Sex Transm Infect. 2013 May;89(3):251-6
pubmed: 23024223
JAMA. 2003 Sep 17;290(11):1510-4
pubmed: 13129993
J Neuroimaging. 2008 Oct;18(4):360-3
pubmed: 18302644
PLoS One. 2015 Dec 08;10(12):e0143304
pubmed: 26646541
Antimicrob Agents Chemother. 1985 Aug;28(2):347-8
pubmed: 3834836
Nat Rev Dis Primers. 2017 Oct 12;3:17073
pubmed: 29022569
Clin Infect Dis. 2004 Apr 1;38(7):1001-6
pubmed: 15034833
Clin Microbiol Rev. 1999 Apr;12(2):187-209
pubmed: 10194456
J Clin Microbiol. 2017 Jun;55(6):1865-1870
pubmed: 28381602
N Engl J Med. 2019 Oct 3;381(14):1358-1363
pubmed: 31577877
Neurology. 2015 Oct 13;85(15):1332-41
pubmed: 26400582