Maresin 1 attenuates pro-inflammatory activation induced by β-amyloid and stimulates its uptake.
Alzheimer's disease
NF-κB
THP-1
chemokines
cytokines
flow cytometry
human
monocyte-derived microglia
pro-resolving
resolution of inflammation
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
17
12
2019
revised:
13
10
2020
accepted:
29
10
2020
pubmed:
24
11
2020
medline:
1
10
2021
entrez:
23
11
2020
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is the most common dementia, characterized by pathological accumulation of β-amyloid (Aβ) and hyperphosphorylation of tau protein, together with a damaging chronic inflammation. The lack of effective treatments urgently warrants new therapeutic strategies. Resolution of inflammation, associated with beneficial and regenerative activities, is mediated by specialized pro-resolving lipid mediators (SPMs) including maresin 1 (MaR1). Decreased levels of MaR1 have been observed in AD brains. However, the pro-resolving role of MaR1 in AD has not been fully investigated. In the present study, human monocyte-derived microglia (MdM) and a differentiated human monocyte cell line (THP-1 cells) exposed to Aβ were used as models of AD neuroinflammation. We have studied the potential of MaR1 to inhibit pro-inflammatory activation of Aβ and assessed its ability to stimulate phagocytosis of Aβ
Identifiants
pubmed: 33225628
doi: 10.1111/jcmm.16098
pmc: PMC7810927
doi:
Substances chimiques
7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid
0
Amyloid beta-Peptides
0
NF-kappa B
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
434-447Subventions
Organisme : The Swedish Brain Foundation
Organisme : Stiftelsen för Gamla Tjänarinnor
Organisme : Gun och Bertil Stohnes Stiftelse
Organisme : The Erik Rönnberg foundation
Organisme : Hjärt-Lungfonden
ID : 20160419
Organisme : The Swedish Alzheimer Foundation
Organisme : China Scholarship Council
Organisme : The Center for Innovative Medicine
Organisme : The Swedish Research Council
Organisme : The Åhlén foundation
Organisme : The Swedish Dementia Foundation
Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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