Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer.
CD44v6
CellSearch®
cancer stem cells
circulating tumor cells
colorectal cancer
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
10 Nov 2020
10 Nov 2020
Historique:
received:
22
07
2020
accepted:
17
10
2020
entrez:
23
11
2020
pubmed:
24
11
2020
medline:
24
11
2020
Statut:
epublish
Résumé
CD44v6, the CD44 isoform mostly involved in cancer cell migration and invasion, has been identified as a functional biomarker and therapeutic target in colon cancer stem cells. We here provide evidence that baseline CD44v6-positive CTC predict treatment failure in patients with metastatic colorectal cancer undergoing first-line chemotherapy. We suggest that CD44v6-positive CTC can be used to early detect intrinsic drug resistance in this cancer type.
Identifiants
pubmed: 33227095
doi: 10.18632/oncotarget.27794
pii: 27794
pmc: PMC7665234
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4115-4122Informations de copyright
Copyright: © 2020 Nicolazzo et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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