Magnetic separation of iron oxide nanoparticles to improve their application for magnetic particle imaging.

Magnetic particle imaging (MPI) is a promising medical imaging technique for visualizing the three-dimensional distribution of tracer materials, specifically iron oxide nanoparticles (IONP). The optimization of magnetic nanoparticles (MNP) plays an essential role to improve the image resolution and sensitivity of imaging techniques. In this work, the optimization of commercial IONP (EMG 700, Ferrotec) coated with anionic surfactants was carried out using magnetic separation (MS) technique, by a low gradient magnetic separation (LGMS) (<15 T m The magnetophoretical behavior of the samples in different concentrations ranging from 2 to 120 mmol l DLS results showed that by increasing the concentration from 2 to 120 mmol l Therefore, LGMS can be considered as a valuable method to narrow and control the size distribution of MNP for MPI.