Role of iRhoms 1 and 2 in Endochondral Ossification.
ADAM17 Protein
/ genetics
Animals
Calcification, Physiologic
/ genetics
Carrier Proteins
/ genetics
Cell Communication
Cell Differentiation
Cell Proliferation
Chondrocytes
/ cytology
Chondrogenesis
/ genetics
Collagen Type II
/ genetics
ErbB Receptors
/ genetics
Gene Expression Regulation
Growth Plate
/ growth & development
Integrases
/ genetics
Membrane Proteins
/ deficiency
Mice
Mice, Knockout
Osteogenesis
/ genetics
Signal Transduction
Transforming Growth Factor alpha
/ genetics
ADAM17
a disintegrin and metalloprotease 17
endochondral ossification
iRhom1, 2
inactive Rhomboid 1, 2
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Nov 2020
19 Nov 2020
Historique:
received:
06
10
2020
revised:
10
11
2020
accepted:
12
11
2020
entrez:
24
11
2020
pubmed:
25
11
2020
medline:
5
3
2021
Statut:
epublish
Résumé
Growth of the axial and appendicular skeleton depends on endochondral ossification, which is controlled by tightly regulated cell-cell interactions in the developing growth plates. Previous studies have uncovered an important role of a disintegrin and metalloprotease 17 (ADAM17) in the normal development of the mineralized zone of hypertrophic chondrocytes during endochondral ossification. ADAM17 regulates EGF-receptor signaling by cleaving EGFR-ligands such as TGFα from their membrane-anchored precursor. The activity of ADAM17 is controlled by two regulatory binding partners, the inactive Rhomboids 1 and 2 (iRhom1, 2), raising questions about their role in endochondral ossification. To address this question, we generated mice lacking iRhom2 (
Identifiants
pubmed: 33227998
pii: ijms21228732
doi: 10.3390/ijms21228732
pmc: PMC7699240
pii:
doi:
Substances chimiques
Carrier Proteins
0
Col2a1 protein, mouse
0
Collagen Type II
0
Membrane Proteins
0
Transforming Growth Factor alpha
0
iRhom1 protein, mouse
0
iRhom2 protein, mouse
0
EGFR protein, mouse
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Cre recombinase
EC 2.7.7.-
Integrases
EC 2.7.7.-
ADAM17 Protein
EC 3.4.24.86
Adam17 protein, mouse
EC 3.4.24.86
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM134907
Pays : United States
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC 2145 SyNergy- ID 390857198
Organisme : NIH HHS
ID : R01 GM64750; R35 GM134907
Pays : United States
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