Disruption of Conscious Access in Psychosis Is Associated with Altered Structural Brain Connectivity.
Adolescent
Adult
Bipolar Disorder
/ diagnostic imaging
Brain
/ diagnostic imaging
Consciousness
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Neural Pathways
/ diagnostic imaging
Perceptual Masking
Psychotic Disorders
/ diagnostic imaging
Schizophrenia
/ diagnostic imaging
Schizophrenic Psychology
Sensory Thresholds
White Matter
/ diagnostic imaging
Young Adult
bipolar disorder
cerebral connectivity
consciousness
global neuronal workspace
schizophrenia
tractography
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
20 01 2021
20 01 2021
Historique:
received:
17
04
2020
revised:
10
08
2020
accepted:
20
09
2020
pubmed:
25
11
2020
medline:
30
3
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
According to global neuronal workspace (GNW) theory, conscious access relies on long-distance cerebral connectivity to allow a global neuronal ignition coding for conscious content. In patients with schizophrenia and bipolar disorder, both alterations in cerebral connectivity and an increased threshold for conscious perception have been reported. The implications of abnormal structural connectivity for disrupted conscious access and the relationship between these two deficits and psychopathology remain unclear. The aim of this study was to determine the extent to which structural connectivity is correlated with consciousness threshold, particularly in psychosis. We used a visual masking paradigm to measure consciousness threshold, and diffusion MRI tractography to assess structural connectivity in 97 humans of either sex with varying degrees of psychosis: healthy control subjects (
Identifiants
pubmed: 33229501
pii: JNEUROSCI.0945-20.2020
doi: 10.1523/JNEUROSCI.0945-20.2020
pmc: PMC7821858
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
513-523Informations de copyright
Copyright © 2021 the authors.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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