A peptide of a type I toxin-antitoxin system induces
Adenosine Triphosphate
/ metabolism
Cell Membrane
/ drug effects
Helicobacter pylori
/ cytology
Hydrogen Peroxide
/ toxicity
Intracellular Space
/ metabolism
Kinetics
Membrane Potentials
/ drug effects
Oxidative Stress
/ drug effects
Peptides
/ pharmacology
Peptidoglycan
/ metabolism
Toxin-Antitoxin Systems
Helicobacter pylori
bacterial morphology
coccoids
dormant bacteria
toxin–antitoxin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 12 2020
08 12 2020
Historique:
pubmed:
25
11
2020
medline:
22
1
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
Toxin-antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging from plasmid stabilization to biofilm formation and persistence. In these systems, the expression/activity of the toxin is counteracted by an antitoxin, which, in type I systems, is an antisense RNA. While the regulatory mechanisms of these systems are mostly well defined, the toxins' biological activity and expression conditions are less understood. Here, these questions were investigated for a type I toxin-antitoxin system (AapA1-IsoA1) expressed from the chromosome of the human pathogen
Identifiants
pubmed: 33229580
pii: 2016195117
doi: 10.1073/pnas.2016195117
pmc: PMC7733810
doi:
Substances chimiques
Peptides
0
Peptidoglycan
0
Adenosine Triphosphate
8L70Q75FXE
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
31398-31409Commentaires et corrections
Type : CommentIn
Type : CommentIn
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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