The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor.
Journal
Biomaterials science
ISSN: 2047-4849
Titre abrégé: Biomater Sci
Pays: England
ID NLM: 101593571
Informations de publication
Date de publication:
07 Dec 2020
07 Dec 2020
Historique:
pubmed:
25
11
2020
medline:
15
12
2020
entrez:
24
11
2020
Statut:
ppublish
Résumé
The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied. The RBD surface comprises a basic amino acid stretch of four arginine residues which interact with the physiological polyP (polyP
Substances chimiques
Antiviral Agents
0
Polyelectrolytes
0
Polymers
0
Polyphosphates
0
Spike Glycoprotein, Coronavirus
0
polyanions
0
spike protein, SARS-CoV-2
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM