Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117
Animals
Antigens, CD34
/ genetics
Antineoplastic Agents, Alkylating
/ toxicity
Biomarkers
/ metabolism
Bone Marrow
/ drug effects
Bone Marrow Cells
/ cytology
Cell Count
Cyclophosphamide
/ antagonists & inhibitors
Female
Gene Expression
Hematopoietic Stem Cells
/ cytology
Immunophenotyping
Injections, Intraperitoneal
Mice
Mice, Inbred C57BL
Plant Extracts
/ chemistry
Polysaccharides
/ isolation & purification
Proto-Oncogene Proteins c-kit
/ genetics
Tussilago
/ chemistry
CD117
CD34
cyclophosphamide
flow cytometry
polysaccharides
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
03
07
2020
pubmed:
25
11
2020
medline:
5
10
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117
Identifiants
pubmed: 33231808
doi: 10.1007/s10517-020-05025-y
pii: 10.1007/s10517-020-05025-y
doi:
Substances chimiques
Antigens, CD34
0
Antineoplastic Agents, Alkylating
0
Biomarkers
0
Plant Extracts
0
Polysaccharides
0
Cyclophosphamide
8N3DW7272P
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM