Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.
ATP-binding cassette (ABC) transporters
cardiovascular disease
cytokine
macrophage
niacinamide
vitamin B3
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
21 11 2020
21 11 2020
Historique:
received:
30
10
2020
revised:
12
11
2020
accepted:
18
11
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
26
11
2020
Statut:
epublish
Résumé
The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic atherosclerosis was significantly reduced (NAM low dose: 45%; NAM high dose: 55%) in NAM-treated, apolipoprotein (Apo)E-deficient mice challenged with a Western diet for 4 weeks. NAM administration significantly increased (1.8-fold) the plasma concentration of proatherogenic ApoB-containing lipoproteins in NAM high-dose (HD)-treated mice compared with untreated mice. However, isolated ApoB-containing lipoproteins from NAM HD mice were less prone to oxidation than those of untreated mice. This result was consistent with the decreased (1.5-fold) concentration of oxidized low-density lipoproteins in this group. Immunohistochemical staining of aortas from NAM-treated mice showed significantly increased levels of IL-10 (NAM low-dose (LD): 1.3-fold; NAM HD: 1.2-fold), concomitant with a significant decrease in the relative expression of TNFα (NAM LD: -44%; NAM HD: -57%). An improved anti-inflammatory pattern was reproduced in macrophages cultured in the presence of NAM. Thus, dietary NAM supplementation in ApoE-deficient mice prevented the development of atherosclerosis and improved protection against ApoB-containing lipoprotein oxidation and aortic inflammation.
Identifiants
pubmed: 33233455
pii: antiox9111162
doi: 10.3390/antiox9111162
pmc: PMC7700561
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI17/00232
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI18/00164
Pays : International
Organisme : Fundació la Marató de TV3
ID : 201602.31
Pays : International
Organisme : Fundació la Marató de TV3
ID : 201605-31
Pays : International
Organisme : Instituto de Salud Carlos III
ID : CPII18/00004
Pays : International
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : FI-DGR2014
Pays : International
Organisme : The National Program Postgraduate Scholarships "DON CARLOS ANTONIO LOPEZ" (BECAL)
ID : BCAL04-451 - 3824321
Pays : International
Organisme : CONICYT (Comisión Nacional de Investigación Científica y Tecnología) fellowship
ID : PFCHA/DOCTORADO BECAS CHILE/2016-72170639
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : RED2018-102799-T
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SAF2017-89510-R
Pays : International
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