Association between Structural Connectivity and Generalized Cognitive Spectrum in Alzheimer's Disease.
alzheimer’s disease
biomarker identification
brain connectivity
diffusion tensor imaging
machine learning
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
20 Nov 2020
20 Nov 2020
Historique:
received:
08
10
2020
revised:
10
11
2020
accepted:
17
11
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
26
11
2020
Statut:
epublish
Résumé
Modeling disease progression through the cognitive scores has become an attractive challenge in the field of computational neuroscience due to its importance for early diagnosis of Alzheimer's disease (AD). Several scores such as Alzheimer's Disease Assessment Scale cognitive total score, Mini Mental State Exam score and Rey Auditory Verbal Learning Test provide a quantitative assessment of the cognitive conditions of the patients and are commonly used as objective criteria for clinical diagnosis of dementia and mild cognitive impairment (MCI). On the other hand, connectivity patterns extracted from diffusion tensor imaging (DTI) have been successfully used to classify AD and MCI subjects with machine learning algorithms proving their potential application in the clinical setting. In this work, we carried out a pilot study to investigate the strength of association between DTI structural connectivity of a mixed ADNI cohort and cognitive spectrum in AD. We developed a machine learning framework to find a generalized cognitive score that summarizes the different functional domains reflected by each cognitive clinical index and to identify the connectivity biomarkers more significantly associated with the score. The results indicate that the efficiency and the centrality of some regions can effectively track cognitive impairment in AD showing a significant correlation with the generalized cognitive score (
Identifiants
pubmed: 33233622
pii: brainsci10110879
doi: 10.3390/brainsci10110879
pmc: PMC7699729
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Gerontol. 1982 May;37(3):323-9
pubmed: 7069156
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
IEEE Trans Biomed Eng. 2019 May;66(5):1195-1206
pubmed: 30222548
Ann Transl Med. 2017 Sep;5(17):351
pubmed: 28936445
Comput Methods Programs Biomed. 2018 Aug;162:19-45
pubmed: 29903486
Arch Neurol. 2008 Aug;65(8):1091-5
pubmed: 18695059
Neuroimage. 1999 May;9(5):534-44
pubmed: 10329293
Neuroscience. 2015 Aug 27;302:103-11
pubmed: 25286385
Front Neurosci. 2017 Feb 28;11:56
pubmed: 28293162
Front Aging Neurosci. 2018 Nov 14;10:365
pubmed: 30487745
Hum Brain Mapp. 2014 May;35(5):2383-93
pubmed: 24039033
Brain Sci. 2020 Jun 11;10(6):
pubmed: 32545374
J Alzheimers Dis. 2018;63(2):423-444
pubmed: 29660938
Stat Methods Med Res. 1992;1(1):69-95
pubmed: 1341653
Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S13-21
pubmed: 9236948
Comput Math Methods Med. 2017;2017:5271627
pubmed: 28352290
AJNR Am J Neuroradiol. 2009 May;30(5):893-9
pubmed: 19279272
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
pubmed: 11293691
Neuroimage. 2014 Oct 15;100:91-105
pubmed: 24911377
Neuroimage. 2012 Jan 16;59(2):895-907
pubmed: 21992749
Neuroimage Clin. 2016 Dec 18;13:415-427
pubmed: 28116234
J Neurol Neurosurg Psychiatry. 2000 Oct;69(4):528-30
pubmed: 10990518
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Cereb Cortex. 2006 Dec;16(12):1701-8
pubmed: 16400164
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
Neuroimage. 2013 Sep;78:233-48
pubmed: 23583359
Alzheimers Dement. 2016 Jun;12(6):645-53
pubmed: 27079753
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Neurobiol Aging. 2016 Oct;46:180-91
pubmed: 27500865
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Neuropsychology. 2008 Jul;22(4):531-44
pubmed: 18590364
Neuroimage. 2015 Nov 15;122:1-5
pubmed: 26241684
Neuroimage. 2012 Sep;62(3):1924-38
pubmed: 22705374
Brain Struct Funct. 2016 Sep;221(7):3787-801
pubmed: 26476928
Am J Psychiatry. 1984 Nov;141(11):1356-64
pubmed: 6496779
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
IEEE Trans Neural Netw Learn Syst. 2017 Jul;28(7):1490-1507
pubmed: 28287983
Netw Neurosci. 2018;2(3):306-322
pubmed: 30259007
Neuroimage. 2010 Jul 15;51(4):1405-13
pubmed: 20347044
Neuroimage Clin. 2020;26:101937
pubmed: 31351845
Neuroimage. 2015 Oct 1;119:338-51
pubmed: 26163802
Hum Brain Mapp. 2015 Aug;36(8):3087-103
pubmed: 26037224
Sci Rep. 2017 May 11;7(1):1719
pubmed: 28496183
Neuroimage. 2010 May 1;50(4):1519-35
pubmed: 20056158
Arch Neurol. 2001 Mar;58(3):397-405
pubmed: 11255443
Alzheimer Dis Assoc Disord. 2010 Oct-Dec;24(4):348-53
pubmed: 20592580
Neuroimage. 2014 Dec;103:411-426
pubmed: 25109526
Trends Cogn Sci. 2013 Dec;17(12):683-96
pubmed: 24231140
Brief Bioinform. 2019 Jan 18;20(1):178-189
pubmed: 28968705
Neuroimage. 2019 Jul 15;195:150-164
pubmed: 30951846
Proc IEEE Int Conf Comput Vis. 2011;:557-562
pubmed: 25283084
Med Image Anal. 2017 May;38:205-214
pubmed: 26674971
Phys Rev Lett. 2001 Nov 5;87(19):198701
pubmed: 11690461
J Neurosci. 2010 Dec 15;30(50):16876-85
pubmed: 21159959
J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):1-12
pubmed: 14741005
Neurobiol Aging. 2012 Jan;33(1):61-74
pubmed: 20371138