Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment.
astrocytes
connexin43
epilepsy
gap junctions
hemichannels
mimetic peptides
seizures
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
20 11 2020
20 11 2020
Historique:
received:
29
09
2020
revised:
17
11
2020
accepted:
18
11
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
7
7
2021
Statut:
epublish
Résumé
In epilepsy research, emphasis is put on exploring non-neuronal targets such as astrocytic proteins, since many patients remain pharmacoresistant to current treatments, which almost all target neuronal mechanisms. This paper reviews available data on astrocytic connexin43 (Cx43) signaling in seizures and epilepsy. Cx43 is a widely expressed transmembrane protein and the constituent of gap junctions (GJs) and hemichannels (HCs), allowing intercellular and extracellular communication, respectively. A plethora of research papers show altered Cx43 mRNA levels, protein expression, phosphorylation state, distribution and/or functional coupling in human epileptic tissue and experimental models. Human Cx43 mutations are linked to seizures as well, as 30% of patients with oculodentodigital dysplasia (ODDD), a rare genetic condition caused by mutations in the GJA1 gene coding for Cx43 protein, exhibit neurological symptoms including seizures. Cx30/Cx43 double knock-out mice show increased susceptibility to evoked epileptiform events in brain slices due to impaired GJ-mediated redistribution of K
Identifiants
pubmed: 33233647
pii: biom10111578
doi: 10.3390/biom10111578
pmc: PMC7699773
pii:
doi:
Substances chimiques
Connexin 43
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vrije Universiteit Brussel
ID : SPR49
Organisme : Vrije Universiteit Brussel
ID : OZR2102
Organisme : Ghent University
ID : Special Research Fund
Organisme : Geneeskundige Stichting Koningin Elisabeth
ID : STI.DI2.2017.0004.01
Organisme : European Research Council, Fund for Scientific Research Flanders-Belgium
ID : G.0A82.13N and G.0527.18N
Organisme : University Hospital of the Vrije Universiteit Brussel-Belgium
ID : Willy Gepts Fonds UZ-VUB
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