Lipopolysaccharide Binding Protein and Bactericidal/Permeability-Increasing Protein as Biomarkers for Invasive Pulmonary Aspergillosis.
Aspergillus
bactericidal/permeability-increasing protein
biomarker
bronchoalveolar lavage
galactomannan
interleukin-8
invasive pulmonary aspergillosis
lipopolysaccharide binding protein
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
20 Nov 2020
20 Nov 2020
Historique:
received:
13
10
2020
revised:
18
11
2020
accepted:
19
11
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
26
11
2020
Statut:
epublish
Résumé
Early diagnosis of invasive pulmonary aspergillosis (IPA) is crucial to prevent lethal disease in immunocompromized hosts. So far, lipopolysaccharide binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) levels have not been evaluated as biomarkers for IPA. IL-8, previously introduced as a biomarker for IPA, was also included in this study. Bronchoalveolar lavage fluid (BALF) of IPA patients and control patients with non-infectious lung disease was collected according to clinical indications. Measurements in BALF displayed significantly higher levels of LBP (
Identifiants
pubmed: 33233831
pii: jof6040304
doi: 10.3390/jof6040304
pmc: PMC7712449
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Bayerische Forschungsstiftung
ID : AZ 1070-13
Organisme : Deutsche Forschungsgemeinschaft
ID : 324392634 - TRR 221(B13)
Organisme : Deutsche Forschungsgemeinschaft
ID : GE 671/14-2
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