Targeting Solute Carrier Transporters through Functional Mapping.

Humans Ligands Membrane Transport Proteins Solute Carrier Proteins
functional mapping protein evolution protein structure solute carriers

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
01 2021
Historique:
received: 04 06 2020
revised: 12 10 2020
accepted: 02 11 2020
pubmed: 26 11 2020
medline: 1 9 2021
entrez: 25 11 2020
Statut: ppublish

Résumé

Solute carrier (SLC) transporters are emerging drug targets. Identifying the molecular determinants responsible for their specific and selective transport activities and describing key interactions with their ligands are crucial steps towards the design of potential new drugs. A general functional mapping across more than 400 human SLC transporters would pave the way to the rational and systematic design of molecules modulating cellular transport.

Identifiants

DOI: 10.1016/j.tips.2020.11.005 PMID: 33234336
pubmed: 33234336
pii: S0165-6147(20)30255-8
doi: 10.1016/j.tips.2020.11.005
pii:
doi:

Substances chimiques

Ligands 0
Membrane Transport Proteins 0
Solute Carrier Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3-6

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Claire Colas (C)

Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090, Wien, Austria. Electronic address: claire.colas@univie.ac.at.

Elodie Laine (E)

Sorbonne Université, UPMC University Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Solute Carrier Transporters through...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Targeting Solute Carrier Transporters through...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Targeting Solute Carrier Transporters through...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Targeting Solute Carrier Transporters through...