The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Acute Disease
Animals
B-Lymphocytes
/ immunology
Brain
/ pathology
Cells, Cultured
Chronic Disease
Dura Mater
/ pathology
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Female
Homeodomain Proteins
/ metabolism
Inflammation
/ immunology
Interleukin-6
/ metabolism
Interleukins
/ metabolism
Lymphocyte Count
Mice, Inbred C57BL
Peptides
/ immunology
T-Lymphocytes, Helper-Inducer
/ immunology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 11 2020
24 11 2020
Historique:
received:
28
05
2020
accepted:
10
11
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
17
4
2021
Statut:
epublish
Résumé
Beyond the major role of T cells in the pathogenesis of the autoimmune neuroinflammatory disorder multiple sclerosis (MS), recent studies have highlighted the impact of B cells on pathogenic inflammatory processes. Follicular T helper cells (Tfh) are essential for the promotion of B cell-driven immune responses. However, their role in MS and its murine model, experimental autoimmune encephalomyelitis (EAE), is poorly investigated. A first step to achieving a better understanding of the contribution of Tfh cells to the disease is the consideration of Tfh cell localization in relation to genetic background and EAE induction method. Here, we investigated the Tfh cell distribution during disease progression in disease relevant organs in three different EAE models. An increase of Tfh frequency in the central nervous system (CNS) was observed during peak of C57BL/6 J EAE, paralleling chronic disease activity, whereas in relapsing-remitting SJL EAE mice Tfh cell frequencies were increased during remission. Furthermore, transferred Tfh-skewed cells polarized in vitro induced mild clinical symptoms in B6.Rag1
Identifiants
pubmed: 33235306
doi: 10.1038/s41598-020-77588-9
pii: 10.1038/s41598-020-77588-9
pmc: PMC7686332
doi:
Substances chimiques
Homeodomain Proteins
0
Interleukin-6
0
Interleukins
0
Peptides
0
RAG-1 protein
128559-51-3
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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