Cancer prevention through weight control-where are we in 2020?
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
28
04
2020
accepted:
22
10
2020
revised:
07
10
2020
pubmed:
26
11
2020
medline:
28
9
2021
entrez:
25
11
2020
Statut:
ppublish
Résumé
Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.
Identifiants
pubmed: 33235315
doi: 10.1038/s41416-020-01154-3
pii: 10.1038/s41416-020-01154-3
pmc: PMC7960959
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1049-1056Subventions
Organisme : Chief Scientist Office
ID : HSRU1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14133
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Investigateurs
Annie Anderson
(A)
Rebecca Beeken
(R)
Janet Cade
(J)
Amanda Cross
(A)
Angela King
(A)
Richard Martin
(R)
Giota Mitrou
(G)
Elio Riboli
(E)
John Saxton
(J)
Andrew Renehan
(A)
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