Cancer survivorship, excess body fatness and weight-loss intervention-where are we in 2020?
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
28
04
2020
accepted:
22
10
2020
revised:
24
09
2020
pubmed:
26
11
2020
medline:
28
9
2021
entrez:
25
11
2020
Statut:
ppublish
Résumé
Earlier diagnosis and more effective treatments mean that the estimated number of cancer survivors in the United Kingdom is expected to reach 4 million by 2030. However, there is an increasing realisation that excess body fatness (EBF) is likely to influence the quality of cancer survivorship and disease-free survival. For decades, the discussion of weight management in patients with cancer has been dominated by concerns about unintentional weight loss, low body weight and interventions to increase weight, often re-enforced by the existence of the obesity paradox, which indicates that high body weight is associated with survival benefits for some types of cancer. However, observational evidence provides strong grounds for testing the hypothesis that interventions for promoting intentional loss of body fat and maintaining skeletal muscle in overweight and obese cancer survivors would bring important health benefits in terms of survival outcomes and long-term impact on treatment-related side effects. In this paper, we outline the need for studies to improve our understanding of the health benefits of weight-loss interventions, such as hypocaloric healthy-eating plans combined with physical activity. In particular, complex intervention trials that are pragmatically designed are urgently needed to develop effective, clinically practical, evidence-based strategies for reducing EBF and optimising body composition in people living with and beyond common cancers.
Identifiants
pubmed: 33235316
doi: 10.1038/s41416-020-01155-2
pii: 10.1038/s41416-020-01155-2
pmc: PMC7961062
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1057-1065Subventions
Organisme : Cancer Research UK
ID : 14133
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 25004
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 27498
Pays : United Kingdom
Organisme : Department of Health
ID : PDF-2016-09-025
Pays : United Kingdom
Investigateurs
Annie Anderson
(A)
Rebecca Beeken
(R)
Janet Cade
(J)
Amanda Cross
(A)
Angela King
(A)
Richard Martin
(R)
Giota Mitrou
(G)
Elio Riboli
(E)
John Saxton
(J)
Andrew Renehan
(A)
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