Are redox changes a critical switch for mitotic progression?
AURKA
kinase activation
mitosis
mitotic kinase
redox regulation
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
23 Oct 2020
23 Oct 2020
Historique:
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
26
11
2020
Statut:
epublish
Résumé
Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
Identifiants
pubmed: 33235921
doi: 10.1080/23723556.2020.1832419
pii: 1832419
pmc: PMC7670999
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1832419Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES015339
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES028374
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM104047
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES020466
Pays : United States
Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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