Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection.
COVID-19
Nasopharyngeal
SARS-CoV-2
Saliva
Transport
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
01
07
2020
accepted:
28
10
2020
pubmed:
26
11
2020
medline:
28
1
2021
entrez:
25
11
2020
Statut:
ppublish
Résumé
Due to global shortages of flocked nasopharyngeal swabs and appropriate viral transport media during the COVID-19 pandemic, alternate diagnostic specimens for SARS-CoV-2 detection are sought. The accuracy and feasibility of saliva samples collected and transported without specialized collection devices or media were evaluated. Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings. SARS-CoV-2 RNA was stable in human saliva at room temperature for up to 48 h after initial specimen collection, informing appropriate transport time and conditions.
Identifiants
pubmed: 33236269
doi: 10.1007/s10096-020-04090-5
pii: 10.1007/s10096-020-04090-5
pmc: PMC7685775
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
447-450Références
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