Immunological basis of virus-host interaction in COVID-19.
COVID-19
Kawasaki disease
children
cytokine storm
immunopathogenesis
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
27
07
2020
accepted:
04
08
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
COVID-19 is a complex new viral disease, in which a strict balance between anti-viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, age-related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVID-19.
Identifiants
pubmed: 33236427
doi: 10.1111/pai.13363
pmc: PMC7753582
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-78Informations de copyright
© 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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