SARS-CoV-2 infection and neonates: a review of evidence and unresolved questions.
2019-nCoV
COVID-19
SARS-CoV-2
neonate
newborn
pregnancy
prematurity
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
22
07
2020
accepted:
04
08
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
SARS-CoV-2 infection in the neonatal period poses previously unmet challenges to obstetricians and neonatologists, but several key questions are yet to be answered. Few cases of presumed in utero vertical transmission of the virus from infected mothers to fetuses have been reported, but stronger evidence is needed, from larger datasets with multiple biospecimens rigorously analyzed. Whether acquired before or after birth, SARS-CoV-2 infection in neonates can be symptomatic, but our comprehension of neonatal immune response and the subsequent clinical characteristics of COVID-19 in early life are incomplete. Finally, the pandemic challenged several dogmas regarding the management of mother-infant dyads, and again more robust data are needed to support the formulation of evidence-based guidelines. Here, we briefly summarize existing evidence and key unresolved questions about SARS-CoV-2 infection and COVID-19 in the neonatal period.
Identifiants
pubmed: 33236433
doi: 10.1111/pai.13349
pmc: PMC7753385
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-81Informations de copyright
© 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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