Contribution of macromolecules to brain
Adult
Aged
Aged, 80 and over
Brain
/ diagnostic imaging
Consensus
Expert Testimony
Humans
Lipids
/ chemistry
Macromolecular Substances
/ metabolism
Magnetic Resonance Imaging
Metabolome
Middle Aged
Models, Theoretical
Proton Magnetic Resonance Spectroscopy
Signal Processing, Computer-Assisted
Young Adult
brain macromolecules
fitting
metabolite quantification
mobile lipids
parameterization
proton magnetic resonance spectroscopy
quantification
spectral analysis
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
08
07
2020
received:
21
11
2019
accepted:
13
07
2020
pubmed:
26
11
2020
medline:
19
1
2022
entrez:
25
11
2020
Statut:
ppublish
Résumé
Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.
Identifiants
pubmed: 33236818
doi: 10.1002/nbm.4393
pmc: PMC10072289
mid: NIHMS1881877
doi:
Substances chimiques
Lipids
0
Macromolecular Substances
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4393Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB027061
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015909
Pays : United States
Organisme : Austrian Science Fund FWF
ID : P 30701
Pays : Austria
Organisme : NIMH NIH HHS
ID : R01 MH109159
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Magn Reson Med. 2005 Oct;54(4):761-8
pubmed: 16161114
Neuroimage. 2014 Apr 1;89:92-109
pubmed: 24345390
Magn Reson Med. 2006 Aug;56(2):386-94
pubmed: 16767752
Magn Reson Med. 2011 Jan;65(1):28-34
pubmed: 20928884
Magn Reson Med. 2014 Oct;72(4):934-40
pubmed: 24407736
NMR Biomed. 2018 Feb;31(2):
pubmed: 29266515
Magn Reson Med. 2002 May;47(5):1009-12
pubmed: 11979581
Magn Reson Med. 2001 Sep;46(3):451-6
pubmed: 11550235
Magn Reson Med. 2002 Apr;47(4):629-33
pubmed: 11948722
NMR Biomed. 2003 May;16(3):123-31
pubmed: 12884355
Neuroimage. 2015 Nov 1;121:126-35
pubmed: 26210813
NMR Biomed. 2013 Jan;26(1):28-34
pubmed: 22730142
Anal Biochem. 2017 Jul 15;529:17-29
pubmed: 27293215
Prog Nucl Magn Reson Spectrosc. 2009 Apr 5;54(3-4):141-165
pubmed: 20160946
NMR Biomed. 2005 Feb;18(1):1-13
pubmed: 15660450
NMR Biomed. 2016 Nov;29(11):1656-1665
pubmed: 27717093
Physiol Chem Phys Med NMR. 1985;17(1):23-33
pubmed: 4034678
Magn Reson Imaging. 2011 Apr;29(3):374-9
pubmed: 21232891
NMR Biomed. 2015 Mar;28(3):291-6
pubmed: 25534141
J Magn Reson Imaging. 2016 Jul;44(1):41-50
pubmed: 26663561
NMR Biomed. 2000 May;13(3):129-53
pubmed: 10861994
Magn Reson Med. 2001 Nov;46(5):855-63
pubmed: 11675635
FEBS Lett. 1982 May 17;141(2):181-4
pubmed: 7095148
NMR Biomed. 2017 Nov;30(11):
pubmed: 28915314
AJNR Am J Neuroradiol. 1997 Aug;18(7):1271-7
pubmed: 9282854
Magn Reson Med. 2015 Sep;74(3):607-13
pubmed: 25252131
Magn Reson Med. 2006 Dec;56(6):1365-70
pubmed: 17051529
J Magn Reson Imaging. 2010 Feb;31(2):289-97
pubmed: 20099340
Magn Reson Med. 2012 Sep;68(3):657-61
pubmed: 22777748
Tomography. 2018 Dec;4(4):172-181
pubmed: 30588503
MAGMA. 2009 Feb;22(1):5-18
pubmed: 18989714
J Neurochem. 1956 Dec;1(2):126-33
pubmed: 13398827
Magn Reson Med. 2019 Feb;81(2):746-758
pubmed: 30329186
Science. 1993 Jun 4;260(5113):1491-6
pubmed: 8502992
Neuroimage. 2006 Oct 15;33(1):85-93
pubmed: 16884929
NMR Biomed. 2012 Feb;25(2):332-9
pubmed: 21796710
Magn Reson Med. 2010 Oct;64(4):939-46
pubmed: 20564591
Magn Reson Med. 2017 Jan;77(1):34-43
pubmed: 26800478
Magn Reson Med. 2004 Jun;51(6):1115-21
pubmed: 15170830
Magn Reson Med. 2015 Jul;74(1):4-12
pubmed: 25081993
NMR Biomed. 2015 Jul;28(7):890-7
pubmed: 25997981
J Magn Reson. 2005 Jan;172(1):9-16
pubmed: 15589402
Anal Biochem. 2017 Jul 15;529:117-126
pubmed: 28034790
Neuroimage. 2014 Dec;103:290-302
pubmed: 25255945
NMR Biomed. 2008 Jun;21(5):507-17
pubmed: 17955570
Magn Reson Med. 1996 Jul;36(1):7-12
pubmed: 8795013
Magn Reson Imaging. 2017 Oct;42:8-15
pubmed: 28479342
Neuroimage. 2017 Oct 1;159:32-45
pubmed: 28716717
Magn Reson Med. 2009 Oct;62(4):862-7
pubmed: 19645007
Curr Opin Struct Biol. 1998 Oct;8(5):640-8
pubmed: 9818270
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5662-6
pubmed: 8516315
J Biol Chem. 1990 Dec 25;265(36):22059-62
pubmed: 2266107
J Magn Reson. 2008 Oct;194(2):163-8
pubmed: 18703364
Magn Reson Med. 2003 Feb;49(2):223-32
pubmed: 12541241
Magn Reson Med. 2012 Apr;67(4):891-7
pubmed: 21748799
MAGMA. 2011 Jun;24(3):147-64
pubmed: 21424575
NMR Biomed. 2008 Aug;21(7):677-85
pubmed: 18186027
Magn Reson Med. 2018 Mar;79(3):1231-1240
pubmed: 28643447
Magn Reson Med. 2018 Aug;80(2):462-473
pubmed: 29334141
Magn Reson Med. 1999 Oct;42(4):636-42
pubmed: 10502751
Magn Reson Med. 1994 Sep;32(3):294-302
pubmed: 7984061
J Magn Reson. 1997 Nov;129(1):35-43
pubmed: 9405214
Magn Reson Med. 2003 Jan;49(1):19-28
pubmed: 12509816
Magn Reson Med. 2014 Oct;72(4):941-8
pubmed: 24407931
Neuroimage. 2019 May 1;191:457-469
pubmed: 30818026
Magn Reson Med. 2005 Jul;54(1):43-50
pubmed: 15968678
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
Magn Reson Med. 2001 Mar;45(3):517-20
pubmed: 11241712
Magn Reson Med. 2017 Sep;78(3):836-847
pubmed: 27797107
J Magn Reson Imaging. 2011 May;33(5):1262-7
pubmed: 21509888
Magn Reson Med. 1991 Feb;17(2):285-303
pubmed: 1676483
NMR Biomed. 1999 Jun;12(4):205-16
pubmed: 10421912
Magn Reson Med. 2018 Dec;80(6):2339-2355
pubmed: 29893995
Magn Reson Med. 2002 Sep;48(3):440-53
pubmed: 12210908
Magn Reson Med. 2003 Jul;50(1):24-32
pubmed: 12815675
Magn Reson Med. 1998 Jan;39(1):6-10
pubmed: 9438430
MAGMA. 2013 Dec;26(6):549-54
pubmed: 23604579
Stroke. 2001 Dec 1;32(12):2797-802
pubmed: 11739976
Magn Reson Med. 2017 Apr;77(4):1390-1398
pubmed: 27018415
J Alzheimers Dis. 2012;31 Suppl 3:S101-15
pubmed: 22543852
Radiology. 2014 Mar;270(3):658-79
pubmed: 24568703
J Neurochem. 1992 Mar;58(3):967-74
pubmed: 1738003
Magn Reson Med. 2003 May;49(5):918-27
pubmed: 12704775
J Magn Reson Imaging. 2002 Nov;16(5):538-46
pubmed: 12412030
Magn Reson Med. 2020 Aug;84(2):542-558
pubmed: 32003506
Nat Struct Biol. 2001 Nov;8(11):923-5
pubmed: 11685234
NMR Biomed. 2021 May;34(5):e4350
pubmed: 32596978
NMR Biomed. 2020 Aug 17;:e4347
pubmed: 32808407
Neurology. 1992 Jul;42(7):1349-54
pubmed: 1620345
Neuroimage. 2010 Nov 1;53(2):392-8
pubmed: 20633664
Neurology. 1990 Nov;40(11):1764-9
pubmed: 2172865
Neuroimage. 2019 Jan 1;184:475-489
pubmed: 30243974
Magn Reson Med. 2018 Mar;79(3):1260-1265
pubmed: 28691380
Magn Reson Med. 2009 Oct;62(4):868-79
pubmed: 19591201
Neuroimage. 2014 Jan 1;84:1111-2
pubmed: 24004693
Magn Reson Med. 2016 Feb;75(2):503-14
pubmed: 25820200
Biochemistry. 1983 Apr 26;22(9):2186-92
pubmed: 6860659
Magn Reson Imaging. 2004 Dec;22(10):1361-72
pubmed: 15707786
MAGMA. 2004 Sep;17(1):36-46
pubmed: 15340855
J Magn Reson. 1999 Nov;141(1):104-20
pubmed: 10527748
NMR Biomed. 1993 Jul-Aug;6(4):242-7
pubmed: 8217525
Magn Reson Med. 1993 Jul;30(1):38-44
pubmed: 8371672
J Cereb Blood Flow Metab. 2000 Apr;20(4):736-46
pubmed: 10779018
J Magn Reson Imaging. 1997 Nov-Dec;7(6):1116-21
pubmed: 9400857
Brain. 2001 May;124(Pt 5):953-61
pubmed: 11335697
J Biol Chem. 1992 May 15;267(14):9905-10
pubmed: 1577821
Magn Reson Med. 2018 Aug;80(2):452-461
pubmed: 29344979
Magn Reson Med. 2011 Apr;65(4):927-48
pubmed: 21337419
NMR Biomed. 2013 May;26(5):593-9
pubmed: 23413241
Magn Reson Med. 1996 May;35(5):633-9
pubmed: 8722812
J Neurochem. 2014 Jun;129(5):806-15
pubmed: 24611713
NMR Biomed. 2021 May;34(5):e4411
pubmed: 32946145
NMR Biomed. 2017 Oct;30(10):
pubmed: 28759166
Magn Reson Med. 2006 Dec;56(6):1200-10
pubmed: 17094090
Neurology. 2005 Feb 8;64(3):434-41
pubmed: 15699371
J Magn Reson Imaging. 2008 Jan;27(1):178-84
pubmed: 18058932
Magn Reson Med. 2018 May;79(5):2460-2469
pubmed: 28868730