A perspective on the safety of parabens as preservatives in wound care products.
allergic contact dermatitis
endocrine disrupting
estrogenic activity
parabens
preservatives
Journal
International wound journal
ISSN: 1742-481X
Titre abrégé: Int Wound J
Pays: England
ID NLM: 101230907
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
23
10
2020
received:
05
08
2020
accepted:
27
10
2020
pubmed:
26
11
2020
medline:
7
8
2021
entrez:
25
11
2020
Statut:
ppublish
Résumé
Antimicrobial and/or preservative ingredients incorporated in wound care products are subjected to certain safety restrictions. However, several of those agents, and paraben preservatives in particular, have been criticised. Conflicting reports on the potential of parabens to induce allergic contact dermatitis, and their assumed oestrogen-like activity, raised public health concerns about their overall safety. Here, we seek to provide a balanced perspective on the most significant purported adverse health effects, and thereby allay the many misconceptions regarding the safety of parabens. Extensive and long-term monitoring of paraben allergy frequencies illustrate that allergic reactions are quite uncommon, especially when compared with other antimicrobial and preservative agents. The estrogenic potential of parabens was illustrated to be far less potent than that of natural oestrogen receptor ligands, and the etiological significance of their presence in human tissue has not been established. The general consensus based on investigations by both the scientific community and regulatory agencies indicates that, with current safety regulations regarding their use in place, this effective and well-documented group of preservatives should not warrant drastic measures to replace them. As such, despite the ongoing concern, it is indicated that, when used at typical concentrations, parabens are unlikely to affect human health.
Identifiants
pubmed: 33236854
doi: 10.1111/iwj.13521
pmc: PMC8243994
doi:
Substances chimiques
Parabens
0
Preservatives, Pharmaceutical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-232Informations de copyright
© 2020 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.
Références
J Wound Care. 2013;22(5 Suppl):S1-89
pubmed: 24645204
J Prev Med Hyg. 2019 Mar 29;60(1):E50-E57
pubmed: 31041411
Australas J Dermatol. 2013 Feb;54(1):31-5
pubmed: 23083503
Br J Dermatol. 2020 Nov;183(5):857-865
pubmed: 32107776
J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1516-1525
pubmed: 28627111
J Appl Toxicol. 2004 Jan-Feb;24(1):5-13
pubmed: 14745841
Contact Dermatitis. 2014 Jul;71(1):35-40
pubmed: 24712382
J Am Acad Dermatol. 2014 Feb;70(2):269-75.e4
pubmed: 24268786
J Eur Acad Dermatol Venereol. 2008 Feb;22(2):174-81
pubmed: 18211410
Dermatitis. 2009 May-Jun;20(3):149-60
pubmed: 19470301
J Appl Toxicol. 2007 Jan-Feb;27(1):67-77
pubmed: 17121429
Adv Skin Wound Care. 2016 Jun;29(6):278-86
pubmed: 27171256
Contact Dermatitis. 2018 Feb;78(2):101-108
pubmed: 29194657
Food Chem Toxicol. 2005 Jul;43(7):985-1015
pubmed: 15833376
Dermatitis. 2019 Jan/Feb;30(1):3-31
pubmed: 30570578
Arch Toxicol. 2016 Nov;90(11):2699-2709
pubmed: 26608183
Dermatitis. 2008 May-Jun;19(3):129-36
pubmed: 18627684
Int J Toxicol. 2001;20 Suppl 3:23-50
pubmed: 11766131
Contact Dermatitis. 1995 Sep;33(3):193-5
pubmed: 8565462
Am J Contact Dermat. 2000 Dec;11(4):207-12
pubmed: 11123412
Reprod Toxicol. 2015 Apr;52:93-100
pubmed: 25728410
J Appl Toxicol. 2005 Jul-Aug;25(4):301-9
pubmed: 16021681
J Appl Toxicol. 2014 Sep;34(9):925-38
pubmed: 25047802
Birth Defects Res B Dev Reprod Toxicol. 2008 Apr;83(2):123-33
pubmed: 18393383
Dermatitis. 2005 Jun;16(2):57-66; quiz 55-6
pubmed: 16036114
Int Wound J. 2021 Apr;18(2):221-232
pubmed: 33236854
Int Wound J. 2013 Dec;10 Suppl 1:9-14
pubmed: 24251838
Food Chem Toxicol. 2005 Feb;43(2):279-91
pubmed: 15621341
Contact Dermatitis. 2011 Jul;65(1):28-33
pubmed: 21309787
Arch Dermatol. 2000 Feb;136(2):272-3
pubmed: 10677115
J Eur Acad Dermatol Venereol. 2017 Apr;31(4):664-671
pubmed: 27896884
Cutis. 2019 Apr;103(4):192-193
pubmed: 31116813
Toxicol Sci. 2000 Mar;54(1):138-53
pubmed: 10746941
Toxicol Ind Health. 2003 Jul;19(2-6):69-79
pubmed: 15697177
Environ Toxicol Chem. 2009 Jan;28(1):204-8
pubmed: 18717622
Toxicol In Vitro. 2005 Jun;19(4):457-69
pubmed: 15826804
J Am Acad Dermatol. 1998 Jun;38(6 Pt 1):911-8
pubmed: 9631997
PLoS One. 2020 Jan 16;15(1):e0217192
pubmed: 31945067
Dermatitis. 2014 Sep-Oct;25(5):215-31
pubmed: 25207684
Food Chem Toxicol. 2004 Nov;42(11):1845-9
pubmed: 15350682
Environ Health Perspect. 2001 Feb;109(2):133-8
pubmed: 11266322
Contact Dermatitis. 2010 Feb;62(2):102-8
pubmed: 20136893
Drug Metab Pharmacokinet. 2010;25(6):568-77
pubmed: 20930423
Contact Dermatitis. 1988 Sep;19(3):189-91
pubmed: 3191679
Food Chem Toxicol. 2000 Apr;38(4):319-23
pubmed: 10722885
Chemosphere. 2004 Dec;57(11):1649-55
pubmed: 15519410
Eur J Dermatol. 2014 Jan-Feb;24(1):3-9
pubmed: 24492204
Contact Dermatitis. 2017 Feb;76(2):81-88
pubmed: 27555055
Toxicol Ind Health. 2001 Feb;17(1):31-9
pubmed: 12004923
Dermatitis. 2004 Dec;15(4):176-83
pubmed: 15842061
Dermatitis. 2017 Jan/Feb;28(1):81-87
pubmed: 28098722
Contact Dermatitis. 2012 Nov;67(5):312-4
pubmed: 23039007
J Appl Toxicol. 2012 Mar;32(3):219-32
pubmed: 22237600
Contact Dermatitis. 2019 Aug;81(2):124-129
pubmed: 30977136
Int J Toxicol. 2008;27 Suppl 4:1-82
pubmed: 19101832
J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:15-24
pubmed: 31588615
Contact Dermatitis. 2009 Jul;61(1):31-8
pubmed: 19659962
Reprod Toxicol. 2010 Sep;30(2):301-12
pubmed: 20381602
Toxicol Appl Pharmacol. 1998 Nov;153(1):12-9
pubmed: 9875295
Contact Dermatitis. 1998 Dec;39(6):320-1
pubmed: 9874032
Br J Dermatol. 2011 Jun;164(6):1316-25
pubmed: 21332463
Dermatitis. 2018 Nov/Dec;29(6):310-315
pubmed: 30422883
Dermatitis. 2017 Jan/Feb;28(1):33-46
pubmed: 27775967
Crit Rev Toxicol. 2005 Jun;35(5):435-58
pubmed: 16097138
Dermatitis. 2018 Nov/Dec;29(6):297-309
pubmed: 30422882
Dermatitis. 2013 Mar-Apr;24(2):50-9
pubmed: 23474444
J Toxicol Environ Health A. 2005 Feb 27;68(4):239-51
pubmed: 15799449
Toxicol In Vitro. 2006 Oct;20(7):1238-48
pubmed: 16797915
Am J Contact Dermat. 2003 Jun;14(2):59-62
pubmed: 14749021
Contact Dermatitis. 2010 May;62(5):309-13
pubmed: 20536479
Contact Dermatitis. 2017 Jun;76(6):350-356
pubmed: 27917496
Dermatitis. 2015 Jan-Feb;26(1):49-59
pubmed: 25581671
Dermatitis. 2013 Jan-Feb;24(1):10-21
pubmed: 23340394
Dermatitis. 2015 Nov-Dec;26(6):254-9
pubmed: 26551603
Curr Opin Allergy Clin Immunol. 2017 Aug;17(4):263-268
pubmed: 28548971
Contact Dermatitis. 1995 Dec;33(6):375-80
pubmed: 8706393
Arch Dermatol. 2008 Jan;144(1):67-72
pubmed: 18209170
Contact Dermatitis. 2002 Apr;46(4):207-10
pubmed: 12081698
J Appl Toxicol. 2014 Sep;34(9):1051-9
pubmed: 24652746
Food Chem Toxicol. 2002 Dec;40(12):1807-13
pubmed: 12419695
Sci Total Environ. 2019 Jun 20;670:555-568
pubmed: 30909033
Contact Dermatitis. 2011 Sep;65(3):167-74
pubmed: 21692811
Trans St Johns Hosp Dermatol Soc. 1963;49:127-40
pubmed: 14116129
Anticancer Res. 2005 May-Jun;25(3c):2543-50
pubmed: 16080490
Contact Dermatitis. 2012 Jul;67(1):9-19
pubmed: 22500724
J Am Acad Dermatol. 2005 Sep;53(3):416-21
pubmed: 16112346
Toxicol Ind Health. 2004 Sep;20(6-10):123-32
pubmed: 15941009
Skin Therapy Lett. 2013 Feb;18(2):5-7
pubmed: 23508773
Eur J Cancer Prev. 2001 Oct;10(5):389-93
pubmed: 11711753
Int Wound J. 2016 Jul;13 Suppl 2:5-15
pubmed: 27460943
Contact Dermatitis. 2005 Sep;53(3):136-45
pubmed: 16128752
Food Chem Toxicol. 2001 Dec;39(12):1225-32
pubmed: 11696396
J Appl Toxicol. 2013 May;33(5):390-8
pubmed: 23364952
Dermatitis. 2014 Mar-Apr;25(2):77-82
pubmed: 24603520
Reprod Toxicol. 2009 Jul;28(1):26-31
pubmed: 19490991
J Steroid Biochem Mol Biol. 2002 Jan;80(1):49-60
pubmed: 11867263
Pharmacol Rep. 2013;65(2):484-93
pubmed: 23744433