Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy.
Adolescent
Adult
Aged
Aged, 80 and over
Basement Membrane
/ pathology
Cogan Syndrome
/ pathology
Cornea
/ pathology
Corneal Pachymetry
/ methods
Corneal Topography
/ methods
Cross-Sectional Studies
Dry Eye Syndromes
/ pathology
Epithelium, Corneal
/ pathology
Female
Fourier Analysis
Humans
Keratoconus
/ pathology
Male
Middle Aged
Tomography, Optical Coherence
/ methods
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
01
2020
accepted:
31
08
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
22
12
2020
Statut:
epublish
Résumé
To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD). 45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects were enrolled. All participants were subjected to 9-mm corneal epithelial mapping with OCT and vision quality was assessed with the optical quality analysis system using the objective scatter index (OSI). Central, superior, inferior, minimum, maximum, and standard deviation of epithelium thickness (Irregularity), were analysed and correlations with the OSI were calculated. The mean (±SD) central, inferior and maximum epithelial thicknesses of the EBMD patients (respectively, 56.4 (±8.1) μm, 58.9 (±6.4) μm, and 67.1 (±8.3) μm) were thicker compared to DED patients (P<0.05) and normal subjects (P<0.05). We found greater irregularity of epithelial thickness in EBMD (5.1±2.5 μm) compared to DED patients (2.6±1.0 μm) (P = 4.4.10-6) and normal subjects (2.1±0.7 μm) (P = 7.6.10-7). The mean OSI was worse in EBMD patients than in DED patients (P = 0.01) and compared to normal subjects (P = 0.02). The OSI correlated with the epithelial thickness irregularity (Spearman coefficient = 0.54; P = 2.65.10-5). The OCT pachymetry map demonstrated that EBMD patients had thicker corneal epithelium in the central and inferior region. These changes were correlated with objective measurements of vision quality. This OCT characterisation of the EMBD provides a better understanding of the epithelial behaviour in this dystrophy and its role in vision quality.
Identifiants
pubmed: 33237913
doi: 10.1371/journal.pone.0239124
pii: PONE-D-20-02872
pmc: PMC7688121
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0239124Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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