Determination of peppermint compounds in breath by needle trap micro-extraction coupled with gas chromatography-tandem mass spectrometry.
GC–MS/MS
VOCs
breath analysis
needle trap micro-extraction
peppermint oil
Journal
Journal of breath research
ISSN: 1752-7163
Titre abrégé: J Breath Res
Pays: England
ID NLM: 101463871
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
12
09
2020
accepted:
25
11
2020
pubmed:
26
11
2020
medline:
11
3
2022
entrez:
25
11
2020
Statut:
epublish
Résumé
Breath analysis is an alternative approach for disease diagnosis and for monitoring therapy. The lack of standardized procedures for collecting and analysing breath samples currently limits its use in clinical practice. In order to overcome this limitation, the 'Peppermint Consortium' was established within the breath community to carry out breath wash-out experiments and define reference values for a panel of compounds contained in the peppermint oil capsule. Here, we present a needle trap micro-extraction technique coupled with gas chromatography and tandem mass spectrometry for a rapid and accurate determination of alpha-pinene, beta-pinene, limonene, eucalyptol, menthofuran, menthone, menthol and menthyl acetate in mixed breath samples. Detection limits between 1 and 20 pptv were observed when 25 ml of a humidified standard gas mixture were loaded into a needle trap device at a flow rate of 10 ml min
Identifiants
pubmed: 33238253
doi: 10.1088/1752-7163/abcdec
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 IOP Publishing Ltd.