Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery.
Chagas disease
Trypanosoma cruzi
clinical trials
drug discovery
proteochemometric
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Nov 2020
23 Nov 2020
Historique:
received:
06
11
2020
revised:
19
11
2020
accepted:
20
11
2020
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Chagas disease still has no effective treatment option for all of its phases despite being discovered more than 100 years ago. The development of commercial drugs has been stagnating since the 1960s, a fact that sheds light on the question of how drug discovery research has progressed and taken advantage of technological advances. Could it be that technological advances have not yet been sufficient to resolve this issue or is there a lack of protocol, validation and standardization of the data generated by different research teams? This work presents an overview of commercial drugs and those that have been evaluated in studies and clinical trials so far. A brief review is made of recent target-based and phenotypic studies based on the search for molecules with anti-
Identifiants
pubmed: 33238613
pii: molecules25225483
doi: 10.3390/molecules25225483
pmc: PMC7700143
pii:
doi:
Substances chimiques
Biomarkers
0
Trypanocidal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 309461/2019-7
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : 26/ 202. 630/2019 [247088]
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