Laccase as an efficacious approach to remove anticancer drugs: A study of doxorubicin degradation, kinetic parameters, and toxicity assessment.

Animals Antineoplastic Agents / toxicity Cell Line Doxorubicin / toxicity Kinetics Laccase / metabolism Mice Water Purification
Anticancer drugs Antineoplastic drugs Enzymatic degradation Oxidoreductases

Journal

Journal of hazardous materials
ISSN: 1873-3336
Titre abrégé: J Hazard Mater
Pays: Netherlands
ID NLM: 9422688

Informations de publication

Date de publication:
05 05 2021
Historique:
received: 18 05 2020
revised: 05 11 2020
accepted: 06 11 2020
pubmed: 27 11 2020
medline: 1 6 2021
entrez: 26 11 2020
Statut: ppublish

Résumé

The degradation of an anticancer drug by laccase was investigated for the first time, bringing a new approach to treat these hazardous substances through the direct enzymatic application. Degradations of doxorubicin by laccase were performed in different enzymatic concentrations, pH values and temperatures through kinetic studies. The highest enzymatic degradation of doxorubicin was achieved at pH 7 and 30 ºC, which resembles effluent characteristics from wastewater treatment plants. Assays were carried out in different doxorubicin concentrations to comprehend the enzymatic kinetics of degradation. Michaelis-Menten kinetic parameters obtained were maximum velocity obtained (V

Identifiants

DOI: 10.1016/j.jhazmat.2020.124520 PMID: 33239208
pubmed: 33239208
pii: S0304-3894(20)32510-3
doi: 10.1016/j.jhazmat.2020.124520
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Doxorubicin 80168379AG
Laccase EC 1.10.3.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

124520

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Maikon Kelbert (M)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: maikonkelbert@gmail.com.

Camila Senna Pereira (CS)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: camilasenna94@gmail.com.

Naionara Ariete Daronch (NA)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: naionaradaronch@gmail.com.

Karina Cesca (K)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: karinacesca@gmail.com.

Camila Michels (C)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: camila.m@ufsc.br.

Débora de Oliveira (D)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: debora.oliveira@ufsc.br.

Hugo Moreira Soares (HM)

Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: hugo.moreira.soares@ufsc.br.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Laccase › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Laccase as an efficacious approach to remove...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Amélioration du niveau sanitaire › Génie sanitaire › Gestion des déchets › Purification de l'eau › Laccase as an efficacious approach to remove...