Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
25 11 2020
25 11 2020
Historique:
received:
17
07
2019
revised:
22
01
2020
accepted:
02
06
2020
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by acute and chronic graft-versus-host disease (GVHD). The impact of obesity on allo-HSCT outcomes is poorly understood. Here, we report that obesity had a negative and selective impact on acute gut GVHD after allo-HSCT in mice with diet-induced obesity (DIO). These animals exhibited increased gut permeability, endotoxin translocation across the gut, and radiation-induced gastrointestinal damage after allo-HSCT. After allo-HSCT, both male and female DIO mouse recipients showed increased proinflammatory cytokine production and expression of the GVHD marker ST2 (IL-33R) and MHC class II molecules; they also exhibited decreased survival associated with acute severe gut GVHD. This rapid-onset, obesity-associated gut GVHD depended on donor CD4
Identifiants
pubmed: 33239390
pii: 12/571/eaay7713
doi: 10.1126/scitranslmed.aay7713
pmc: PMC8525601
mid: NIHMS1742820
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA093373
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK092993
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA065493
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118979
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI034495
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155114
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214048
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL056067
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA039542
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK110421
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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