Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration.
Absorbable Implants
Animals
Disease Models, Animal
Electric Stimulation Therapy
/ instrumentation
Female
Humans
Materials Testing
Muscle, Skeletal
/ innervation
Peripheral Nerve Injuries
/ therapy
Polyurethanes
/ chemistry
Rats
Regeneration
Sciatic Nerve
/ injuries
Wireless Technology
/ instrumentation
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 11 2020
25 11 2020
Historique:
received:
28
05
2020
accepted:
19
10
2020
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, to eliminate the need for surgical extraction. Our findings overcome key challenges of bioresorbable electronic devices by realizing lifetimes that match clinical needs. The devices exploit a bioresorbable dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components. We describe the underlying features and chemical design considerations for this polymer, and the biocompatibility of its constituent materials. In devices with optimized, wireless designs, these polymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve injuries, thereby demonstrating the potential of programmable long-term electrical stimulation for maintaining muscle receptivity and enhancing functional recovery.
Identifiants
pubmed: 33239608
doi: 10.1038/s41467-020-19660-6
pii: 10.1038/s41467-020-19660-6
pmc: PMC7688647
doi:
Substances chimiques
Polyurethanes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5990Commentaires et corrections
Type : ErratumIn
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