The genetic architecture of sporadic and multiple consecutive miscarriage.

Abortion, Habitual / epidemiology Abortion, Spontaneous / epidemiology Adult Aged Case-Control Studies Datasets as Topic Female Gene Frequency Genetic Predisposition to Disease Genome-Wide Association Study Humans Inheritance Patterns Medical History Taking Middle Aged Placenta / physiopathology Polymorphism, Single Nucleotide Pregnancy White People / genetics Young Adult

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
25 11 2020
Historique:
received: 16 09 2019
accepted: 23 10 2020
entrez: 26 11 2020
pubmed: 27 11 2020
medline: 15 12 2020
Statut: epublish

Résumé

Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366, minor allele frequency (MAF) 1.2%, P = 3.2 × 10

Identifiants

DOI: 10.1038/s41467-020-19742-5 PMID: 33239672 PMC: PMC7689465
pubmed: 33239672
doi: 10.1038/s41467-020-19742-5
pii: 10.1038/s41467-020-19742-5
pmc: PMC7689465
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5980

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201600001C
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : British Heart Foundation
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12026/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT088806
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC-PC-13049
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG004424
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14135
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG005152
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201600003C
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD097296
Pays : United States
Organisme : NIEHS NIH HHS
ID : N01ES75558
Pays : United States
Organisme : Wellcome Trust
ID : 203141/Z/16/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N02 HL64278
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202922/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC-PC-14135
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201600002C
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00017/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201600004C
Pays : United States
Organisme : Medical Research Council
ID : MC_U137686851
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201600018C
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103246
Pays : United States
Organisme : Wellcome Trust
ID : 088158/Z/09/Z
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG005157
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13049
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215/2/13/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104085/Z/14/Z
Pays : United Kingdom

Références

Fertil Steril. 2017 Jan;107(1):150-159.e2
pubmed: 27842992
Mol Hum Reprod. 2011 Jun;17(6):379-85
pubmed: 21257601
Endocrinology. 2014 May;155(5):1908-20
pubmed: 24605829
Nature. 2016 Aug 17;536(7616):285-91
pubmed: 27535533
Nat Commun. 2017 Nov 28;8(1):1826
pubmed: 29184056
Cell Rep. 2016 Nov 15;17(8):2042-2059
pubmed: 27851967
Dev Cell. 2012 Apr 17;22(4):849-62
pubmed: 22516201
J Soc Gynecol Investig. 2004 Sep;11(6):342-52
pubmed: 15350246
Genet Epidemiol. 2013 Nov;37(7):658-65
pubmed: 24114802
Nat Protoc. 2014 May;9(5):1192-212
pubmed: 24762786
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Int J Epidemiol. 2017 Oct 5;47(1):29-35
pubmed: 29040602
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Mol Hum Reprod. 2019 Dec 1;25(12):811-824
pubmed: 31778538
Nucleic Acids Res. 2019 Jan 8;47(D1):D801-D806
pubmed: 30407599
Am J Epidemiol. 2013 Oct 1;178(7):1177-84
pubmed: 23863760
Nature. 2018 Jun;558(7708):73-79
pubmed: 29875488
Front Genet. 2019 Jun 11;10:550
pubmed: 31244887
Acta Obstet Gynecol Scand. 1990;69(7-8):597-601
pubmed: 2094140
Reprod Sci. 2010 Jun;17(6):578-84
pubmed: 20305137
Fertil Steril. 2013 Jan;99(1):63
pubmed: 23095139
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Nat Genet. 2018 Jul;50(7):906-908
pubmed: 29892013
Heart. 2015 Dec;101(24):1954-60
pubmed: 26246401
PLoS Genet. 2014 May 15;10(5):e1004383
pubmed: 24830394
Hum Reprod Open. 2018 Apr 06;2018(2):hoy004
pubmed: 31486805
Sci Rep. 2016 Dec 08;6:38439
pubmed: 27929073
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Hum Reprod. 2009 Nov;24(11):2683-7
pubmed: 19801627
Cell. 2016 Nov 17;167(5):1369-1384.e19
pubmed: 27863249
Genome Biol. 2018 Oct 4;19(1):151
pubmed: 30286773
JAMA. 2014 Apr 16;311(15):1536-46
pubmed: 24737366
Hum Reprod. 2015 Mar;30(3):495-8
pubmed: 25376455
PLoS One. 2010 Apr 21;5(4):e10258
pubmed: 20422011
Epidemiology. 1991 Jan;2(1):33-9
pubmed: 2021664
Hum Mol Genet. 2017 Sep 15;26(18):3639-3650
pubmed: 28911207
BJOG. 2007 Sep;114(9):1138-45
pubmed: 17655731
Clin Gastroenterol Hepatol. 2012 Aug;10(8):902-9
pubmed: 22373726
Fertil Steril. 2003 Mar;79(3):577-84
pubmed: 12620443
BMC Pregnancy Childbirth. 2017 Dec 22;17(1):437
pubmed: 29272996
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Bioinformatics. 2017 Jan 15;33(2):272-279
pubmed: 27663502
J Obstet Gynaecol Res. 2018 May;44(5):852-860
pubmed: 29442402
Nat Genet. 2017 Aug;49(8):1255-1260
pubmed: 28628106
Nat Genet. 2014 Mar;46(3):310-5
pubmed: 24487276
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
BMC Med. 2013 Jun 26;11:154
pubmed: 23803387
Genome Biol. 2015 Nov 05;16:240
pubmed: 26537248
J Biol Chem. 2005 Sep 2;280(35):30975-83
pubmed: 16002402
BMJ. 2000 Jun 24;320(7251):1708-12
pubmed: 10864550
Am J Reprod Immunol. 1992 Apr-May;27(3-4):128-9
pubmed: 1418404
Alcohol Clin Exp Res. 2019 Aug;43(8):1606-1616
pubmed: 31194258
Mol Cell Biol. 2005 Dec;25(24):10916-29
pubmed: 16314515
NPJ Genom Med. 2019 Apr 15;4:8
pubmed: 30993004
Am J Epidemiol. 2014 Apr 1;179(7):807-23
pubmed: 24518810
Br J Haematol. 2016 Jul;174(2):302-9
pubmed: 27061416
Hum Reprod. 2013 Apr;28(4):908-15
pubmed: 23427230
Hum Reprod. 2006 Sep;21(9):2216-22
pubmed: 16707507
Reprod Biol. 2012 Jul;12(2):183-99
pubmed: 22850470
Conserv Genet. 2018;19(4):995-1005
pubmed: 30100824
Endocrinology. 2007 Aug;148(8):3711-21
pubmed: 17494997
Nat Genet. 2019 Feb;51(2):237-244
pubmed: 30643251
Nature. 2015 Feb 12;518(7538):197-206
pubmed: 25673413
Cell Physiol Biochem. 2017;42(6):2318-2329
pubmed: 28848153
Nature. 2015 Feb 19;518(7539):331-6
pubmed: 25693564
Int J Gynecol Cancer. 2014 Mar;24(3):384-93
pubmed: 24463639
N Engl J Med. 1988 Jul 28;319(4):189-94
pubmed: 3393170
BJOG. 2018 Jul;125(8):983-990
pubmed: 29266732

Auteurs

Triin Laisk (T)

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia. triin.laisk@ut.ee.
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. triin.laisk@ut.ee.
Competence Centre on Health Technologies, Tartu, Estonia. triin.laisk@ut.ee.
ORCID: 0000-0003-1501-9030

Ana Luiza G Soares (ALG)

MRC Integrated Epidemiology Unit at the University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0003-2763-4647

Teresa Ferreira (T)

Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.

Jodie N Painter (JN)

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
ORCID: 0000-0002-4992-2458

Jenny C Censin (JC)

Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
ORCID: 0000-0001-6625-6074

Samantha Laber (S)

Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Jonas Bacelis (J)

Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden.
ORCID: 0000-0002-2450-732X

Chia-Yen Chen (CY)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Maarja Lepamets (M)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Kuang Lin (K)

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Siyang Liu (S)

BGI-Shenzhen, Shenzhen, 518083, Guangdong, China.
Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200, Copenhagen, Denmark.

Iona Y Millwood (IY)

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK.

Avinash Ramu (A)

Department of Genetics, Washington University in St. Louis, Saint Louis, MO, USA.

Jennifer Southcombe (J)

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.

Marianne S Andersen (MS)

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Ling Yang (L)

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK.

Christian M Becker (CM)

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
ORCID: 0000-0002-9870-9581

Anders D Børglum (AD)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
Center for Genomics and Personalized Medicine, Aarhus University and University Hospital, Aarhus, Denmark.
ORCID: 0000-0001-8627-7219

Scott D Gordon (SD)

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
ORCID: 0000-0001-7623-328X

Jonas Bybjerg-Grauholm (J)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
ORCID: 0000-0003-1705-4008

Øyvind Helgeland (Ø)

Department of Genetics and Bioinformatics, Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.

David M Hougaard (DM)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
ORCID: 0000-0001-5928-3517

Xin Jin (X)

BGI-Shenzhen, Shenzhen, 518083, Guangdong, China.
School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China.

Stefan Johansson (S)

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.
Department of Medical Genetics, Haukeland University Hospital, N-5021, Bergen, Norway.
ORCID: 0000-0002-2298-7008

Julius Juodakis (J)

Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0001-5600-974X

Christiana Kartsonaki (C)

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK.

Viktorija Kukushkina (V)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Penelope A Lind (PA)

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
ORCID: 0000-0002-3887-2598

Andres Metspalu (A)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-3718-796X

Grant W Montgomery (GW)

University of Queensland, St Lucia, QLD, Australia.
ORCID: 0000-0002-4140-8139

Andrew P Morris (AP)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Biostatistics, University of Liverpool, Liverpool, UK.
ORCID: 0000-0002-6805-6014

Ole Mors (O)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.

Preben B Mortensen (PB)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.

Pål R Njølstad (PR)

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.
Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
ORCID: 0000-0003-0304-6728

Merete Nordentoft (M)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Copenhagen University Hospital, Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.

Dale R Nyholt (DR)

School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
ORCID: 0000-0001-7159-3040

Margaret Lippincott (M)

Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.

Stephanie Seminara (S)

Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.

Andres Salumets (A)

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Competence Centre on Health Technologies, Tartu, Estonia.
Institute of Bio- and Translational Medicine, University of Tartu, Tartu, Estonia.
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Harold Snieder (H)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-1949-2298

Krina Zondervan (K)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
ORCID: 0000-0002-0275-9905

Thomas Werge (T)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-1829-0766

Zhengming Chen (Z)

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0001-6423-105X

Donald F Conrad (DF)

Department of Genetics, Washington University in St. Louis, Saint Louis, MO, USA.

Bo Jacobsson (B)

Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden.
Department of Genetics and Bioinformatics, Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
ORCID: 0000-0001-5079-2374

Liming Li (L)

Department of Epidemiology & Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.
ORCID: 0000-0001-5873-7089

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
ORCID: 0000-0003-4069-8020

Benjamin M Neale (BM)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0003-1513-6077

Rasmus Nielsen (R)

Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-0513-6591

Robin G Walters (RG)

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK.
ORCID: 0000-0002-9179-0321

Ingrid Granne (I)

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.

Sarah E Medland (SE)

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
ORCID: 0000-0003-1382-380X

Reedik Mägi (R)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Deborah A Lawlor (DA)

MRC Integrated Epidemiology Unit at the University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Bristol National Institute of Health Research Biomedical Research Centre, Bristol, UK.
ORCID: 0000-0002-6793-2262

Cecilia M Lindgren (CM)

Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK. cecilia.lindgren@bdi.ox.ac.uk.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. cecilia.lindgren@bdi.ox.ac.uk.
Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA. cecilia.lindgren@bdi.ox.ac.uk.
ORCID: 0000-0002-4903-9374

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Avortements à répétition › The genetic architecture of sporadic and...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Avortement spontané › The genetic architecture of sporadic and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The genetic architecture of sporadic and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The genetic architecture of sporadic and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › The genetic architecture of sporadic and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Jeux de données comme sujet › The genetic architecture of sporadic and...
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › The genetic architecture of sporadic and...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › The genetic architecture of sporadic and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › The genetic architecture of sporadic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The genetic architecture of sporadic and...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › The genetic architecture of sporadic and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Recueil de l'anamnèse › The genetic architecture of sporadic and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The genetic architecture of sporadic and...
questionsmedicales.fr › Structures de l'embryon › Placenta › The genetic architecture of sporadic and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The genetic architecture of sporadic and...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › The genetic architecture of sporadic and...
questionsmedicales.fr › Personnes › Blancs › The genetic architecture of sporadic and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › The genetic architecture of sporadic and...