A case of spontaneous nephroblastoma characterized by two distinct morphologies in a Slc:CD(SD)IGS rat.
blastemal type
epithelial type
nephroblastoma
rat
two distinct morphologies
Journal
Journal of toxicologic pathology
ISSN: 0914-9198
Titre abrégé: J Toxicol Pathol
Pays: Japan
ID NLM: 9306408
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
02
03
2020
accepted:
24
06
2020
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
27
11
2020
Statut:
ppublish
Résumé
We report a spontaneous case of nephroblastoma in a 26-week-old female Slc:CD(SD) rat. Macroscopically, there was a yellow mass in the left kidney that included another small yellowish-white mass. Histologically, the mass was located mainly in the cortex of the kidney. The tumor showed two distinct morphologies corresponding to the macroscopic findings: a blastemal cell dominant area (blastemal area) with primitive glomeruli and immature tubules and a columnar epithelial tubule dominant area with blastemal cell cuffing on (epithelial area). The epithelial area was located inside the blastemal area and the two morphologies were characterized by the lack of a transition region. Nephroblastoma is known to be biphasic or triphasic and showing transitional features. To our knowledge, there is no report of such nephroblastoma comprising two histologically distinct areas without transition. Therefore, the two distinct morphologies of this case with no transitional characteristic is a rare feature in nephroblastoma.
Identifiants
pubmed: 33239847
doi: 10.1293/tox.2020-0013
pii: 2020-0013
pmc: PMC7677627
doi:
Types de publication
Case Reports
Langues
eng
Pagination
291-295Informations de copyright
©2020 The Japanese Society of Toxicologic Pathology.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
Références
J Toxicol Pathol. 2011 Mar;24(1):37-40
pubmed: 22272042
Vet Pathol. 2002 Sep;39(5):588-9
pubmed: 12243471
J Toxicol Pathol. 2017 Jan;30(1):79-107
pubmed: 28190929
Toxicol Pathol. 2011 Dec;39(7):1115-28
pubmed: 22006284
Toxicol Pathol. 2012 Jun;40(4 Suppl):14S-86S
pubmed: 22637735
Genes Dev. 2015 Mar 1;29(5):467-82
pubmed: 25737276
J Toxicol Pathol. 2014 Apr;27(1):91-5
pubmed: 24791073
Acta Anat (Basel). 1996;156(3):187-201
pubmed: 9124036
J Toxicol Pathol. 2013 Jun;26(2):141-8
pubmed: 23914056
Neoplasma. 1980;27(3):229-35
pubmed: 6256671
World J Nephrol. 2012 Aug 6;1(4):92-9
pubmed: 24175246
Development. 1993 Nov;119(3):711-20
pubmed: 8187639