A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE).
cell free DNA testing
fetal aneuploidy detection
invasive testing
prenatal genetic counseling
randomized-controlled trial
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
05
2020
accepted:
05
10
2020
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
27
11
2020
Statut:
epublish
Résumé
To assess the impact of prenatal genetic counseling on the attitudes and preferences toward invasive testing in first-trimester pregnant women. This is a randomized open-label study, of pregnant women undergoing first trimester combined screening for aneuploidies. Women were divided into the experimental or control groups in a 1:1 design. The intervention consisted of 15-min extra counseling about prenatal screening and diagnosis. The main outcome was the desire to choose an invasive testing as their first prenatal testing option which was measured as absolute risk. After excluding those with incomplete data, 75 women remained in the experimental group and 75 as controls. Women receiving counseling were 32% more likely to choose an invasive prenatal testing as their first-line option after extra 15-min extensive counseling, reducing the first-trimester combined screening by 20% and the cell-free DNA by 12%. If given the opportunity, 59% of the women would like to be able to choose the prenatal test that suits their needs. Women given an extensive prenatal counseling are more likely to choose an invasive testing as their first-line test in spite of the concerning risks. www.ClinicalTrials.gov, identifier NCT04119349.
Identifiants
pubmed: 33240315
doi: 10.3389/fgene.2020.561283
pmc: PMC7682740
doi:
Banques de données
ClinicalTrials.gov
['NCT04119349']
Types de publication
Journal Article
Langues
eng
Pagination
561283Informations de copyright
Copyright © 2020 Paz y Miño, Martinez-Portilla, Pauta and Borrell.
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