Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment.

amino acid transport carbonic anhydrase IX hypoxia tumor metabolism tumor microenvironment

Journal

Frontiers in cell and developmental biology

ISSN: 2296-634X

Titre abrégé: Front Cell Dev Biol

Pays: Switzerland

ID NLM: 101630250

Informations de publication

Date de publication:
2020

Historique:

received: 04 09 2020

accepted: 09 10 2020

entrez: 26 11 2020

pubmed: 27 11 2020

medline: 27 11 2020

Statut: epublish

Résumé

Solid tumors are challenged with a hypoxic and nutrient-deprived microenvironment. Hence, hypoxic tumor cells coordinatively increase the expression of nutrient transporters and pH regulators to adapt and meet their bioenergetic and biosynthetic demands. Carbonic Anhydrase IX (CAIX) is a membrane-bound enzyme that plays a vital role in pH regulation in the tumor microenvironment (TME). Numerous studies have established the importance of CAIX in mediating tumor progression and metastasis. To understand the mechanism of CAIX in mediating tumor progression, we performed an unbiased proteomic screen to identify the potential interactors of CAIX in the TME using the proximity-dependent biotin identification (BioID) technique. In this review, we focus on the interactors from this BioID screen that are crucial for nutrient and metabolite transport in the TME. We discuss the role of transport metabolon comprising CAIX and bicarbonate transporters in regulating intra- and extracellular pH of the tumor. We also discuss the role of amino acid transporters that are high confidence interactors of CAIX, in optimizing favorable metabolic state for tumor progression, and give our perspective on the coordinative interplay of CAIX with the amino acid transporters in the hypoxic TME.

Identifiants

DOI: 10.3389/fcell.2020.602668 PMID: 33240897 PMC: PMC7680889

pubmed: 33240897

doi: 10.3389/fcell.2020.602668

pmc: PMC7680889

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

602668

Informations de copyright

Références

Nature. 2011 Nov 20;481(7381):380-4

pubmed: 22101433

Nat Rev Cancer. 2017 Oct;17(10):577-593

pubmed: 28912578

Sci Rep. 2014 Mar 19;4:4410

pubmed: 24642931

Int J Cancer. 2016 Dec 1;139(11):2529-39

pubmed: 27486861

Am J Physiol Cell Physiol. 2001 Oct;281(4):C1077-93

pubmed: 11546643

Oncotarget. 2012 Jan;3(1):84-97

pubmed: 22289741

J Biol Chem. 2009 Jul 24;284(30):20299-310

pubmed: 19458084

Endocr Relat Cancer. 2006 Sep;13(3):921-30

pubmed: 16954440

Cancer Immunol Res. 2019 Jul;7(7):1064-1078

pubmed: 31088846

Front Cell Dev Biol. 2020 Jul 17;8:651

pubmed: 32766253

Nat Commun. 2017 Jul 03;8:15965

pubmed: 28671190

Front Cell Dev Biol. 2020 Jul 08;8:603

pubmed: 32733894

Cell. 2016 Jun 30;166(1):126-39

pubmed: 27368101

Oncogene. 2016 Jun 16;35(24):3201-8

pubmed: 26455325

J Clin Oncol. 2001 Aug 15;19(16):3660-8

pubmed: 11504747

J Med Chem. 2012 Jun 14;55(11):5591-600

pubmed: 22621623

Chem Rev. 2012 Aug 8;112(8):4421-68

pubmed: 22607219

J Med Chem. 2011 Mar 24;54(6):1896-902

pubmed: 21361354

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12079-84

pubmed: 10518579

Int J Mol Sci. 2020 Jun 16;21(12):

pubmed: 32560271

Int J Mol Sci. 2019 Jun 04;20(11):

pubmed: 31167468

Oncogenesis. 2017 Jul 31;6(7):e367

pubmed: 28759021

Am J Transl Res. 2015 Jun 15;7(6):1161-71

pubmed: 26279759

J Biol Chem. 2017 Oct 13;292(41):16825-16832

pubmed: 28842498

Cancer Cell. 2015 Mar 9;27(3):354-69

pubmed: 25759021

Nat Struct Mol Biol. 2018 Jun;25(6):515-521

pubmed: 29872227

Int J Cancer. 2014 Sep 1;135(5):1060-71

pubmed: 24531984

Cancer Cell. 2012 Mar 20;21(3):297-308

pubmed: 22439925

Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):355-60

pubmed: 15625115

Cell Stem Cell. 2014 Aug 7;15(2):169-84

pubmed: 24953180

Nat Rev Clin Oncol. 2017 Jan;14(1):11-31

pubmed: 27141887

Oncotarget. 2017 Sep 12;8(44):77819-77835

pubmed: 29100428

J Biol Chem. 2016 Jun 17;291(25):13194-205

pubmed: 27129276

Cancer Discov. 2020 Jul;10(7):1018-1037

pubmed: 32341021

J Biol Chem. 2001 Mar 23;276(12):8746-52

pubmed: 11121428

J Biol Chem. 2007 Jul 6;282(27):19788-98

pubmed: 17488712

Nat Cell Biol. 2019 Nov;21(11):1425-1435

pubmed: 31685994

Metabolites. 2018 Feb 28;8(1):

pubmed: 29495652

Pharmacol Ther. 2009 Jan;121(1):29-40

pubmed: 18992769

Cell Cycle. 2018;17(9):1056-1067

pubmed: 29895196

Cancers (Basel). 2020 Apr 07;12(4):

pubmed: 32272695

Cancer. 2009 Apr 1;115(7):1448-58

pubmed: 19195047

Nat Med. 2018 Feb;24(2):194-202

pubmed: 29334372

Br J Cancer. 2009 Mar 24;100(6):874-80

pubmed: 19240720

Cancer Res. 2009 Jan 1;69(1):358-68

pubmed: 19118021

Nat Commun. 2019 Jan 14;10(1):201

pubmed: 30643150

Cancer Res. 2014 Oct 1;74(19):5507-19

pubmed: 25085245

JCI Insight. 2017 Dec 21;2(24):

pubmed: 29263302

PLoS One. 2016 Dec 30;11(12):e0168907

pubmed: 28036362

Pflugers Arch. 2004 Feb;447(5):784-95

pubmed: 12845534

Clin Cancer Res. 2012 Jun 1;18(11):3100-11

pubmed: 22498007

J Cancer Res Clin Oncol. 2018 May;144(5):821-833

pubmed: 29435734

Cancer Res. 2015 Mar 15;75(6):996-1008

pubmed: 25623234

Br J Cancer. 2010 May 25;102(11):1627-35

pubmed: 20461082

Front Physiol. 2013 Oct 10;4:291

pubmed: 24133456

Biochem J. 2006 May 1;395(3):517-27

pubmed: 16445384

Cell Signal. 2014 Aug;26(8):1668-79

pubmed: 24726839

Biochem J. 2006 Jul 15;397(2):369-75

pubmed: 16629640

Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77

pubmed: 21921921

J Biol Chem. 2019 Mar 15;294(11):4012-4026

pubmed: 30635397

Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):15-22

pubmed: 30006019

Trends Biochem Sci. 2010 Aug;35(8):427-33

pubmed: 20570523

Oncotarget. 2018 Jun 15;9(46):27940-27957

pubmed: 29963253

Cell. 2009 Feb 6;136(3):521-34

pubmed: 19203585

Br J Cancer. 2014 Apr 15;110(8):2030-9

pubmed: 24603303

Cancers (Basel). 2020 Jul 22;12(8):

pubmed: 32707920

Subcell Biochem. 2014;75:255-69

pubmed: 24146383

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E603-13

pubmed: 19158318

Nat Genet. 2009 May;41(5):585-90

pubmed: 19330027

Int J Cancer. 2013 Mar 15;132(6):1288-99

pubmed: 22907202

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16233-8

pubmed: 19805286

Biochim Biophys Acta. 2016 Aug;1866(1):76-86

pubmed: 27343712

J Biol Chem. 2014 Jan 31;289(5):2765-75

pubmed: 24338019

J Biol Chem. 1998 Sep 11;273(37):23629-32

pubmed: 9726963

Immunity. 2014 May 15;40(5):692-705

pubmed: 24792914

Histopathology. 2015 Jan;66(2):234-43

pubmed: 24845232

Sci Rep. 2015 Sep 04;5:13605

pubmed: 26337752

Gastroenterology. 2019 Sep;157(3):823-837

pubmed: 31078621

J Pathol. 2015 Jan;235(1):90-100

pubmed: 25142020

J Pathol. 2015 Jul;236(3):278-89

pubmed: 25693838

Oncogene. 2016 Apr 21;35(16):2112-22

pubmed: 26212013

Mol Cell. 2015 Nov 19;60(4):514-23

pubmed: 26590711

Cancer Res. 2011 May 1;71(9):3364-76

pubmed: 21415165

Biochim Biophys Acta Biomembr. 2018 Jul;1860(7):1460-1469

pubmed: 29678469

Oncogene. 2017 Nov 9;36(45):6244-6261

pubmed: 28692057

Int J Mol Sci. 2017 Jul 27;18(8):

pubmed: 28749408

J Cell Biol. 2012 Mar 19;196(6):801-10

pubmed: 22412018

Pharmacol Res. 2020 Aug;158:104844

pubmed: 32438035

Cancer Cell. 2018 May 14;33(5):905-921.e5

pubmed: 29763624

Br J Cancer. 2009 Jan 27;100(2):405-11

pubmed: 19165203

Immunity. 2014 May 15;40(5):635-7

pubmed: 24837098

Nat Commun. 2018 Jan 2;9(1):38

pubmed: 29295993

J Biol Chem. 1996 Jun 21;271(25):14883-90

pubmed: 8662767

Int J Mol Sci. 2020 Jul 31;21(15):

pubmed: 32752017

Genomics. 1996 May 1;33(3):480-7

pubmed: 8661007

Anticancer Res. 2002 Sep-Oct;22(5):2555-7

pubmed: 12529963

Oncogene. 2010 Dec 16;29(50):6509-21

pubmed: 20890298

Expert Opin Investig Drugs. 2018 Dec;27(12):963-970

pubmed: 30426805

Cancer Chemother Pharmacol. 2018 Jan;81(1):141-153

pubmed: 29149426

Oncogene. 2013 Oct 31;32(44):5210-9

pubmed: 23208505

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12452-12461

pubmed: 31152137

Cell Rep. 2017 Dec 26;21(13):3819-3832

pubmed: 29281830

Melanoma Res. 2015 Oct;25(5):399-405

pubmed: 26237765

Clin Cancer Res. 2001 Nov;7(11):3399-403

pubmed: 11705854

Nat Rev Cancer. 2016 Sep 23;16(10):663-73

pubmed: 27658636

Front Oncol. 2020 Sep 02;10:1462

pubmed: 32983978

Cancer Res. 2000 Dec 15;60(24):7075-83

pubmed: 11156414

Cancer Res. 2015 May 1;75(9):1782-8

pubmed: 25855379

Cell. 2017 Oct 5;171(2):358-371.e9

pubmed: 28985563

Science. 2016 Jan 1;351(6268):43-8

pubmed: 26449471

J Enzyme Inhib Med Chem. 2020 Dec;35(1):1185-1193

pubmed: 32396749

Am J Clin Oncol. 2020 Jul;43(7):484-490

pubmed: 32251122

Breast Cancer Res. 2017 Oct 11;19(1):112

pubmed: 29020998

Cancer Cell. 2015 Mar 9;27(3):317-9

pubmed: 25759015

Front Cell Dev Biol. 2018 Sep 04;6:96

pubmed: 30234109

Sci Rep. 2015 Nov 24;5:16954

pubmed: 26599282

Nature. 2019 Apr;568(7750):127-130

pubmed: 30867591

Cancer Res. 2001 Sep 1;61(17):6394-9

pubmed: 11522632