Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis.
Programmed death ligand 1
head and neck
immunohistochemistry
larynx
squamous cell carcinoma
Journal
Clinical pathology (Thousand Oaks, Ventura County, Calif.)
ISSN: 2632-010X
Titre abrégé: Clin Pathol
Pays: United States
ID NLM: 101741182
Informations de publication
Date de publication:
Historique:
received:
02
06
2020
accepted:
14
09
2020
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
27
11
2020
Statut:
epublish
Résumé
We aimed to show the immunohistochemical expression of programmed death ligand 1 (PD-L1) in laryngeal squamous cell carcinomas (SCCs). The study includes 52 laryngeal SCC cases that underwent surgical resection. Immunohistochemical staining of PD-L1 (Clone 22C3) was applied to the sections obtained from paraffin blocks. Combined Positive Score (CPS) was evaluated as described in manuals. Tumor Proportion Score (TPS) was assessed by the percentage of positive tumor cells which were designated as positive if ⩾1% of the tumor cells showed membranous staining. There were 35 cases (67.3%) having CPS < 1 and 17 cases (32.7%) having CPS ⩾ 1. There was no relationship between CPS, TPS, and the clinicopathological data. Further studies with a large number of advanced-stage cases are needed.
Identifiants
pubmed: 33241207
doi: 10.1177/2632010X20964846
pii: 10.1177_2632010X20964846
pmc: PMC7672728
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2632010X20964846Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12293-7
pubmed: 12218188
Head Neck Pathol. 2013 Jun;7(2):113-21
pubmed: 23179191
Appl Immunohistochem Mol Morphol. 2018 Aug;26(7):e79-e85
pubmed: 29271789
Oral Oncol. 2011 Dec;47(12):1148-53
pubmed: 21911310
Clin Cancer Res. 2016 Feb 1;22(3):704-13
pubmed: 26408403
Laryngoscope Investig Otolaryngol. 2017 May 17;2(3):99-103
pubmed: 28894827
Arch Pathol Lab Med. 2017 Jun;141(6):851-861
pubmed: 28418281
Cancer Res. 2013 Jan 1;73(1):128-38
pubmed: 23135914
Cancer Res Treat. 2016 Apr;48(2):527-36
pubmed: 26511814
Mol Cancer Ther. 2018 Mar;17(3):710-716
pubmed: 29440293
Oncotarget. 2017 May 2;8(32):52889-52900
pubmed: 28881780