Reversible lung fibrosis in a 6-year-old girl after long term nitrofurantoin treatment.
Anti-Infective Agents, Urinary
/ administration & dosage
Child
Female
Forced Expiratory Volume
/ physiology
Humans
Long-Term Care
Nitrofurantoin
/ administration & dosage
Pulmonary Fibrosis
/ chemically induced
Tomography, X-Ray Computed
Urinary Tract Infections
/ drug therapy
Vital Capacity
/ physiology
Lung fibrosis
Nitrofurantoin
Paediatrics
Side effects
Urinary tract infection
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
26 Nov 2020
26 Nov 2020
Historique:
received:
12
09
2020
accepted:
19
11
2020
entrez:
27
11
2020
pubmed:
28
11
2020
medline:
10
8
2021
Statut:
epublish
Résumé
Pulmonary side effects are well known, including lung fibrosis, in elderly patients treated with long-term nitrofurantoin to prevent urinary tract infections and secondary renal injury. However, pulmonary side effects have only been reported rarely in paediatric cases, despite nitrofurantoin being a first line prophylactic treatment of recurrent childhood urinary tract infection. A 6-year-old girl was admitted to the hospital with dyspnea, general fatigue, loss of appetite and need for nasal oxygen treatment after long-term nitrofurantoin treatment. A computed tomography scan of the chest showed lung fibrosis. A biopsy confirmed this diagnosis. We suspected the fibrosis to be caused by the nitrofurantoin treatment. Thorough examinations reveal no other explanations. Nitrofurantoin was discontinued and the girl was treated with methylprednisolone. After 17 month a new scan and lung function test showed total regression of the lung fibrosis. This case underlines that risk of severe side effects should be taken in to account before initiation of long-term nitrofurantoin treatment in children.
Sections du résumé
BACKGROUND
BACKGROUND
Pulmonary side effects are well known, including lung fibrosis, in elderly patients treated with long-term nitrofurantoin to prevent urinary tract infections and secondary renal injury. However, pulmonary side effects have only been reported rarely in paediatric cases, despite nitrofurantoin being a first line prophylactic treatment of recurrent childhood urinary tract infection.
CASE PRESENTATIONS
METHODS
A 6-year-old girl was admitted to the hospital with dyspnea, general fatigue, loss of appetite and need for nasal oxygen treatment after long-term nitrofurantoin treatment. A computed tomography scan of the chest showed lung fibrosis. A biopsy confirmed this diagnosis. We suspected the fibrosis to be caused by the nitrofurantoin treatment. Thorough examinations reveal no other explanations. Nitrofurantoin was discontinued and the girl was treated with methylprednisolone. After 17 month a new scan and lung function test showed total regression of the lung fibrosis.
CONCLUSIONS
CONCLUSIONS
This case underlines that risk of severe side effects should be taken in to account before initiation of long-term nitrofurantoin treatment in children.
Identifiants
pubmed: 33243181
doi: 10.1186/s12890-020-01353-x
pii: 10.1186/s12890-020-01353-x
pmc: PMC7689986
doi:
Substances chimiques
Anti-Infective Agents, Urinary
0
Nitrofurantoin
927AH8112L
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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