The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish.
BPA
Estrone
Low-dose effects
Neurotoxicity
Non-monotonic response
Zebrafish
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
25 Feb 2021
25 Feb 2021
Historique:
received:
30
07
2020
revised:
12
10
2020
accepted:
09
11
2020
pubmed:
28
11
2020
medline:
7
1
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Estrone and BPA are two endocrine disrupting chemicals (EDCs) that are predicted to be less potent than estrogens such as 17β-estradiol and 17α-ethinylestradiol. Human exposure concentrations to estrone and BPA can be as low as nanomolar levels. However, very few toxicological studies have focused on the nanomolar-dose effects. Low level of EDCs can potentially cause non-monotonic responses. In addition, exposures at different developmental stages can lead to different health outcomes. To identify the nanomolar-dose effects of estrone and BPA, we used zebrafish modeling to study the phenotypic and transcriptomic responses after extended duration exposure from 0 to 5 days post-fertilization (dpf) and short-term exposure at days 4-5 post fertilization. We found that non-monotonic transcriptomic responses occurred after extended duration exposures at 1 nM of estrone or BPA. At this level, estrone also caused hypoactivity locomotive behavior in zebrafish. After both extended duration and short-term exposures, BPA led to more apparent phenotypic responses, i.e. skeletal abnormalities and locomotion changes, and more significant transcriptomic responses than estrone exposure. After short-term exposure, BPA at concentrations equal or above 100 nM affected locomotive behavior and changed the expression of both estrogenic and non-estrogenic genes that are linked to neurological diseases. These data provide gaps of mechanisms between neurological genes expression and associated phenotypic response due to estrone or BPA exposures. This study also provides insights for assessing the acceptable concentration of BPA and estrone in aquatic environments.
Identifiants
pubmed: 33243503
pii: S0048-9697(20)37267-3
doi: 10.1016/j.scitotenv.2020.143736
pmc: PMC7790172
mid: NIHMS1650874
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Endocrine Disruptors
0
Phenols
0
Estrone
2DI9HA706A
bisphenol A
MLT3645I99
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
143736Subventions
Organisme : NIEHS NIH HHS
ID : F31 ES030278
Pays : United States
Organisme : NIH HHS
ID : K01 OD010462
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES020957
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030722
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Mol Cell Proteomics. 2007 May;6(5):895-907
pubmed: 17264069
Chemosphere. 2017 Feb;169:262-270
pubmed: 27880925
J Neuroendocrinol. 2015 May;27(5):303-23
pubmed: 25737004
PLoS One. 2019 Mar 28;14(3):e0214198
pubmed: 30921354
Hepatology. 2012 Feb;55(2):395-407
pubmed: 21932408
Int J Biochem Cell Biol. 2013 Oct;45(10):2158-62
pubmed: 23769948
BMC Dev Biol. 2006 Jul 26;6:36
pubmed: 16872490
Cell Death Dis. 2015 Oct 29;6:e1959
pubmed: 26512966
Reprod Toxicol. 2013 Dec;42:256-68
pubmed: 23892310
Environ Pollut. 2017 Oct;229:40-48
pubmed: 28577381
J Biol Chem. 2006 Jun 16;281(24):16625-31
pubmed: 16606610
J Biol Chem. 2009 Apr 10;284(15):9947-54
pubmed: 19228692
Aquat Toxicol. 2008 Jun 2;88(1):1-8
pubmed: 18453010
Dev Biol. 2014 Jan 1;385(1):67-82
pubmed: 24161523
J Clin Endocrinol Metab. 2002 Nov;87(11):5185-90
pubmed: 12414890
Menopause. 2015 Dec;22(12):1276-84
pubmed: 26382314
Sci Rep. 2017 May 10;7(1):1661
pubmed: 28490809
Neurosci Lett. 2012 May 31;517(2):136-9
pubmed: 22561649
Environ Int. 2010 Aug;36(6):557-62
pubmed: 20452023
Environ Toxicol Chem. 2002 Oct;21(10):2146-56
pubmed: 12371491
Sci Rep. 2017 Jan 09;7:40024
pubmed: 28067297
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10996-1001
pubmed: 20534480
Environ Sci Technol. 2018 Jan 16;52(2):821-830
pubmed: 29224359
PLoS One. 2013 Aug 05;8(8):e71741
pubmed: 23940784
Neurobiol Aging. 2018 Dec;72:188.e3-188.e12
pubmed: 30201328
J Vet Sci. 2007 Mar;8(1):27-38
pubmed: 17322771
BMC Med Genet. 2019 May 31;20(1):95
pubmed: 31151415
Folia Biol (Praha). 2016;62(4):139-47
pubmed: 27643579
Biomed Pharmacother. 2019 Sep;117:109182
pubmed: 31387175
J Pharmacol Sci. 2015 Jan;127(1):30-5
pubmed: 25704015
Inflammation. 2015 Apr;38(2):637-48
pubmed: 25047101
Environ Sci Technol. 2017 Apr 18;51(8):4705-4713
pubmed: 28328210
Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11
pubmed: 16246168
Cell. 2016 Dec 1;167(6):1481-1494.e18
pubmed: 27912058
Cell Mol Neurobiol. 2009 Jun;29(4):475-83
pubmed: 19130215
Environ Toxicol Chem. 2007 Apr;26(4):732-7
pubmed: 17447558
J Environ Manage. 2015 Apr 1;152:192-200
pubmed: 25684568
J Chromatogr A. 2004 Aug 6;1045(1-2):85-92
pubmed: 15378882
Oncotarget. 2016 Feb 2;7(5):5690-701
pubmed: 26744317
Reprod Toxicol. 2007 Aug-Sep;24(2):139-77
pubmed: 17825522
Environ Health Perspect. 2012 Mar;120(3):464-70
pubmed: 21900077
Environ Res. 2019 Sep;176:108575
pubmed: 31299621
Environ Toxicol Chem. 2013 Jun;32(6):1344-53
pubmed: 23423942
Endocrinology. 2004 Jul;145(7):3062-4
pubmed: 15198969
J Antimicrob Chemother. 2003 Jan;51(1):9-11
pubmed: 12493781
Stem Cell Res Ther. 2018 May 11;9(1):132
pubmed: 29751779
PLoS One. 2011;6(12):e28273
pubmed: 22194820
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7916-21
pubmed: 23620518
Commun Integr Biol. 2013 Nov 1;6(6):e26839
pubmed: 24563715
Front Genet. 2019 Mar 08;10:184
pubmed: 30906313
Prostaglandins Leukot Essent Fatty Acids. 2012 Apr;86(4-5):141-7
pubmed: 22495065
Biosci Rep. 2012 Dec 06;33(1):57-69
pubmed: 23050906
PLoS One. 2012;7(9):e45352
pubmed: 23028956
Dose Response. 2015 Jul 29;13(3):1559325815598308
pubmed: 26674671
J Endocrinol. 1998 Sep;158(3):327-39
pubmed: 9846162
Dose Response. 2015 Oct 07;13(4):1559325815610582
pubmed: 26740804
Environ Sci Technol. 2012 Jan 3;46(1):51-9
pubmed: 21786754
Cell Rep. 2018 Jan 9;22(2):456-470
pubmed: 29320740
Cell Metab. 2015 Feb 3;21(2):334-347
pubmed: 25651185
Environ Monit Assess. 2015 Oct;188(10):562
pubmed: 27624744
Endocr Rev. 2012 Jun;33(3):378-455
pubmed: 22419778
Horm Res. 2006;65(5):217-22
pubmed: 16569931
Environ Sci Technol. 2018 Jun 19;52(12):7120-7130
pubmed: 29782159
Aquat Toxicol. 2016 Jun;175:286-98
pubmed: 27107150
Toxicology. 2012 Jan 27;291(1-3):83-92
pubmed: 22108044
Ann Neurol. 2011 Dec;70(6):913-9
pubmed: 21842496
Toxicol Sci. 2010 May;115(1):1-11
pubmed: 19955490
Gene. 2013 Oct 15;529(1):7-15
pubmed: 23939472
Sci Total Environ. 2005 Jan 5;336(1-3):155-70
pubmed: 15589256
Reprod Toxicol. 2010 Dec;30(4):532-9
pubmed: 20656017
Environ Health Perspect. 2009 May;117(5):778-83
pubmed: 19479021
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13994-9
pubmed: 14610279
Sci Rep. 2018 Feb 8;8(1):2629
pubmed: 29422555
Arch Toxicol. 2015 Nov;89(11):2177-84
pubmed: 26486796
Genes Cells. 2017 Jul;22(7):662-669
pubmed: 28488382
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1475-80
pubmed: 25583509
Nature. 2012 May 16;485(7399):512-6
pubmed: 22622580
Prog Neurobiol. 2006 Feb;78(2):117-34
pubmed: 16457939
Eur J Hum Genet. 2017 Feb;25(2):208-215
pubmed: 27924807
Meta Gene. 2014 May 15;2:366-73
pubmed: 25606421
Mol Biol Rep. 2019 Apr;46(2):2533-2540
pubmed: 30689188
Dev Biol. 2018 May 1;437(1):1-16
pubmed: 29477341
Altern Med Rev. 2005 Mar;10(1):36-41
pubmed: 15771561
Reprod Toxicol. 2007 Aug-Sep;24(2):178-98
pubmed: 17628395
Environ Pollut. 2017 Dec;231(Pt 1):22-36
pubmed: 28780062
Trends Endocrinol Metab. 2016 May;27(5):335-347
pubmed: 27025788
Ecotoxicol Environ Saf. 2019 Jun 15;174:181-188
pubmed: 30826544
Neuropsychopharmacology. 2016 Aug;41(9):2303-8
pubmed: 26924680
Sci Total Environ. 2010 Nov 15;408(24):6062-9
pubmed: 20934204
Nature. 1999 Oct 14;401(6754):670-7
pubmed: 10537105
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1597-E1606
pubmed: 28196890
Dev Dyn. 2018 Dec;247(12):1264-1275
pubmed: 30358936
J Cell Biol. 2006 Oct 9;175(1):77-85
pubmed: 17030984
Aquat Toxicol. 2012 Apr;110-111:114-22
pubmed: 22281776
Chemosphere. 2020 Apr;245:125632
pubmed: 31864044
J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):83-95
pubmed: 21827855
Int J Mol Sci. 2019 Apr 08;20(7):
pubmed: 30965663
Environ Toxicol Chem. 2012 Jun;31(6):1396-406
pubmed: 22488680
J Reprod Dev. 2015;61(3):237-40
pubmed: 25754072
PLoS One. 2013 Nov 06;8(11):e79020
pubmed: 24223173
Gen Comp Endocrinol. 2015 Apr 1;214:195-219
pubmed: 25277515
Environ Sci Technol. 2019 Jan 2;53(1):463-474
pubmed: 30520632
Endocrinology. 2004 Dec;145(12):5485-92
pubmed: 15345672
PLoS One. 2016 Oct 27;11(10):e0164241
pubmed: 27788154
Mol Autism. 2018 Feb 13;9:11
pubmed: 29456827