Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review.
cohort study
maternal health
obstetrics
systematic review
Journal
BMJ global health
ISSN: 2059-7908
Titre abrégé: BMJ Glob Health
Pays: England
ID NLM: 101685275
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
14
08
2020
revised:
22
09
2020
accepted:
23
09
2020
entrez:
27
11
2020
pubmed:
28
11
2020
medline:
25
6
2021
Statut:
ppublish
Résumé
Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography, and high-income country data may not generalise to low-resource settings. We conducted a systematic review to identify prospective pregnancy cohorts in sub-Saharan Africa (SSA) that include biobanked samples with potential to enhance discovery science opportunity. Inclusion criteria were prospective data collection during pregnancy, with associated biobanking in SSA. Data sources included: scientific databases (with comprehensive search terms), grey literature, hand searching applicable reference lists and expert input. Results were screened in a three-stage process based on title, abstract and full text by two independent reviewers. The review is registered on PROSPERO (CRD42019147483). Fourteen SSA studies met the inclusion criteria from database searches (n=8), reference list searches (n=2) and expert input (n=4). Three studies have ongoing data collection. The most represented countries were South Africa and Mozambique (Southern Africa) (n=3), Benin (Western Africa) (n=4) and Tanzania (Eastern Africa) (n=4); including an estimated 31 763 women. Samples commonly collected were blood, cord blood and placenta. Seven studies collected neonatal samples. Common clinical outcomes included maternal and perinatal mortality, malaria and preterm birth. Increasingly numerous pregnancy cohorts in SSA that include biobanking are generating a uniquely valuable resource for collaborative discovery science, and improved understanding of the high regional risks of maternal, fetal and neonatal morbidity and mortality. Future studies should align protocols and consider their added value and distinct contributions.
Sections du résumé
BACKGROUND
Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography, and high-income country data may not generalise to low-resource settings. We conducted a systematic review to identify prospective pregnancy cohorts in sub-Saharan Africa (SSA) that include biobanked samples with potential to enhance discovery science opportunity.
METHODS
Inclusion criteria were prospective data collection during pregnancy, with associated biobanking in SSA. Data sources included: scientific databases (with comprehensive search terms), grey literature, hand searching applicable reference lists and expert input. Results were screened in a three-stage process based on title, abstract and full text by two independent reviewers. The review is registered on PROSPERO (CRD42019147483).
RESULTS
Fourteen SSA studies met the inclusion criteria from database searches (n=8), reference list searches (n=2) and expert input (n=4). Three studies have ongoing data collection. The most represented countries were South Africa and Mozambique (Southern Africa) (n=3), Benin (Western Africa) (n=4) and Tanzania (Eastern Africa) (n=4); including an estimated 31 763 women. Samples commonly collected were blood, cord blood and placenta. Seven studies collected neonatal samples. Common clinical outcomes included maternal and perinatal mortality, malaria and preterm birth.
CONCLUSIONS
Increasingly numerous pregnancy cohorts in SSA that include biobanking are generating a uniquely valuable resource for collaborative discovery science, and improved understanding of the high regional risks of maternal, fetal and neonatal morbidity and mortality. Future studies should align protocols and consider their added value and distinct contributions.
Identifiants
pubmed: 33243854
pii: bmjgh-2020-003716
doi: 10.1136/bmjgh-2020-003716
pmc: PMC7692823
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/P027938/1
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2014-05-019
Pays : United Kingdom
Investigateurs
Umberto D'Alessandro
(U)
Anna Roca
(A)
Hawanatu Jah
(H)
Ofordile Oguchukwu
(O)
Andrew Prentice
(A)
Melisa Martinez-Alvarez
(M)
Brahima Diallo
(B)
Adbul Sesey
(A)
Kodou Lette
(K)
Alpha Bah
(A)
Chilel Sanyang
(C)
Marleen Temmerman
(M)
Angela Koech Etyang
(AK)
Peris Musitia
(P)
Mary Amondi
(M)
David Chege
(D)
Patricia Okiro
(P)
Geoffrey Omuse
(G)
Sikolia Wanyonyi
(S)
Esperança Sevene
(E)
Paulo Chin
(P)
Corssino Tchavana
(C)
Salésio Macuácua
(S)
Anifa Vála
(A)
Helena Boene
(H)
Lazaro Quimice
(L)
Sonia Maculuve
(S)
Eusebio Macete
(E)
Inacio Mandomando
(I)
Carla Carillho
(C)
Peter von Dadelszen
(P)
Laura A Magee
(LA)
Meriel Flint-O'Kane
(M)
Rachel Craik
(R)
Amber Strang
(A)
Marina Daniele
(M)
Donna Russell
(D)
Tatenda Makanga
(T)
Liberty Makacha
(L)
Yolisa Dube
(Y)
Newton Nyapwere
(N)
Lucilla Poston
(L)
Jane Sandall
(J)
Rachel Tribe
(R)
Andrew Shennan
(A)
Sophie Moore
(S)
Tatiana Salisbury
(T)
Ben Barratt
(B)
Sean Beevers
(S)
Kate Bramham
(K)
Aris Papageorgiou
(A)
Alison Noble
(A)
Hannah Blencowe
(H)
Veronique Filippi
(V)
Joy Lawn
(J)
Matt Silver
(M)
Matthew Chico
(M)
Judith Cartwright
(J)
Guy Whitley
(G)
Sanjeev Krishna
(S)
Marianne Vidler
(M)
Jing Larry Li
(JL)
Jeffrey Bone
(J)
Mai-Lei Maggie Woo Kinshella
(MM)
Beth A Payne
(BA)
Domena Tu
(D)
Warancha Tumtaweetikul
(W)
William Stones
(W)
Marie-Laure Volvert
(ML)
Lucy Chappell
(L)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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