Protein storytelling through physics.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
27 11 2020
27 11 2020
Historique:
entrez:
27
11
2020
pubmed:
28
11
2020
medline:
20
1
2021
Statut:
ppublish
Résumé
Every protein has a story-how it folds, what it binds, its biological actions, and how it misbehaves in aging or disease. Stories are often inferred from a protein's shape (i.e., its structure). But increasingly, stories are told using computational molecular physics (CMP). CMP is rooted in the principled physics of driving forces and reveals granular detail of conformational populations in space and time. Recent advances are accessing longer time scales, larger actions, and blind testing, enabling more of biology's stories to be told in the language of atomistic physics.
Identifiants
pubmed: 33243857
pii: 370/6520/eaaz3041
doi: 10.1126/science.aaz3041
pmc: PMC7945008
mid: NIHMS1676765
pii:
doi:
Substances chimiques
Proteins
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM107104
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125813
Pays : United States
Organisme : NIGMS NIH HHS
ID : RM1 GM135136
Pays : United States
Informations de copyright
Copyright © 2020, American Association for the Advancement of Science.
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