Cortical Complexity in People at Ultra-High-Risk for Psychosis Moderated by Childhood Trauma.
cortical complexity
magnetic resonance imaging (MRI)
psychosis
schizophrenia
spherical harmonics
ultra-high risk (UHR)
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
08
2020
accepted:
19
10
2020
entrez:
27
11
2020
pubmed:
28
11
2020
medline:
28
11
2020
Statut:
epublish
Résumé
Subjects with ultra-high risk (UHR) states for psychosis show brain structural volume changes similar to first-episode psychosis and also elevated incidence of environmental risk factors like childhood trauma. It is unclear, however, whether early neurodevelopmental trajectories are altered in UHR. We screened a total of 12,779 first-year Chinese students to enroll 36 UHR subjects (based on clinical interviews) and 59 non-UHR healthy controls for a case-control study of markers of early neurodevelopment. Subjects underwent 3T MRI scanning and clinical characterization, including the childhood trauma questionnaire (CTQ). We then used the CAT12 toolbox to analyse structural brain scans for cortical surface complexity, a spherical harmonics-based marker of early neurodevelopmental changes. While we did not find statistically significant differences between the groups, a trend level finding for reduced cortical complexity (CC) in UHR vs. non-UHR subjects emerged in the left superior temporal cortex (and adjacent insular and transverse temporal cortices), and this trend level association was significantly moderated by childhood trauma (CTQ score). Our findings indicate that UHR subjects tend to show abnormal cortical surface morphometry, in line with recent research; more importantly, however, this association seems to be considerably modulated by early environmental impacts. Hence, our results provide an indication of environmental or gene × environment interactions on early neurodevelopment leading up to elevated psychosis risk.
Identifiants
pubmed: 33244301
doi: 10.3389/fpsyt.2020.594466
pmc: PMC7685197
doi:
Types de publication
Journal Article
Langues
eng
Pagination
594466Informations de copyright
Copyright © 2020 Hou, Schmitt, Meller, Falkenberg, Chen, Wang, Zhao, Shi and Nenadić.
Références
Schizophr Res. 2011 Aug;130(1-3):101-5
pubmed: 21684722
Schizophr Bull. 2003;29(4):703-15
pubmed: 14989408
Eur Psychiatry. 2017 Feb;40:65-75
pubmed: 27992836
Psychiatry Res. 2015 Aug 30;228(3):664-70
pubmed: 26165958
Early Interv Psychiatry. 2013 Nov;7(4):414-20
pubmed: 23343404
Schizophr Bull. 2012 Nov;38(6):1288-96
pubmed: 22516147
Stat Methods Med Res. 2003 Oct;12(5):419-46
pubmed: 14599004
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Schizophr Res. 2014 Nov;159(2-3):278-83
pubmed: 25242361
Behav Res Ther. 2017 Nov;98:39-57
pubmed: 27865431
Psychol Med. 2016 Dec;46(16):3339-3348
pubmed: 27619196
Schizophr Bull. 2014 Jul;40(4):744-55
pubmed: 23770934
Am J Psychiatry. 2002 Jul;159(7):1080-92
pubmed: 12091183
Schizophr Res. 2013 Jan;143(1):185-91
pubmed: 23178105
Schizophr Res. 2018 Dec;202:195-202
pubmed: 30049600
World Psychiatry. 2016 Jun;15(2):118-24
pubmed: 27265696
Braz J Psychiatry. 2012 Dec;34(4):480-8
pubmed: 23429820
Schizophr Bull. 2008 Nov;34(6):1083-94
pubmed: 18635675
Neuroimage. 2016 Jul 1;134:617-629
pubmed: 27103141
Schizophr Res. 2012 May;137(1-3):73-9
pubmed: 22353995
Hum Brain Mapp. 2011 Jul;32(7):1109-24
pubmed: 20665722
Int J Imaging Syst Technol. 2008 Jun 1;18(1):42-68
pubmed: 19936261
Psychiatry Res Neuroimaging. 2017 May 30;263:44-47
pubmed: 28324693
Schizophr Bull. 2012 Nov;38(6):1162-9
pubmed: 21799213
Neurosci Biobehav Rev. 2019 Dec;107:492-504
pubmed: 31163206
Eur Psychiatry. 2015 Mar;30(3):388-404
pubmed: 25749390
Am J Psychiatry. 2004 Jun;161(6):1121-4
pubmed: 15169705
Schizophr Bull. 2014 Jan;40(1):120-31
pubmed: 23180756
PLoS One. 2016 Feb 09;11(2):e0148935
pubmed: 26859774
Psychiatry Clin Neurosci. 2018 Aug;72(8):556-571
pubmed: 29717522
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 May;4(5):434-443
pubmed: 31054647
Schizophr Res. 2018 May;195:589-590
pubmed: 28916135
Biol Psychiatry. 2011 May 15;69(10):974-9
pubmed: 21257157
Psychiatry Investig. 2019 Mar;16(3):234-243
pubmed: 30934191
Expert Rev Neurother. 2013 Jan;13(1):37-47
pubmed: 23253390
Schizophr Bull. 2016 Jul;42 Suppl 1:S127-32
pubmed: 26656880
Schizophr Bull. 2005 Oct;31(4):795-9
pubmed: 16150958
Neuropsychiatr Dis Treat. 2018 Jul 19;14:1861-1869
pubmed: 30050300
Anat Embryol (Berl). 1988;179(2):173-9
pubmed: 3232854
Hum Brain Mapp. 2014 Apr;35(4):1691-9
pubmed: 23813686
Schizophr Res. 2015 Feb;161(2-3):143-9
pubmed: 25499046
Biol Psychiatry. 2017 Jan 1;81(1):9-20
pubmed: 27720198
Schizophr Bull. 2014 May;40(3):697-706
pubmed: 23455040
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Nat Rev Neurosci. 2019 Mar;20(3):161-176
pubmed: 30610227
Soc Psychiatry Psychiatr Epidemiol. 2019 Sep;54(9):1045-1054
pubmed: 31209522
World J Biol Psychiatry. 2016 Jun;17(4):285-95
pubmed: 26453061
J Nerv Ment Dis. 2015 May;203(5):336-41
pubmed: 25900551
Aust N Z J Psychiatry. 2017 May;51(5):500-508
pubmed: 28415873
Psychol Med. 2018 Sep;48(12):1925-1936
pubmed: 29334044
Schizophr Bull. 2019 Jan 1;45(1):169-179
pubmed: 29385604
Hum Brain Mapp. 2018 Mar;39(3):1283-1290
pubmed: 29250891
Am J Psychiatry. 2002 Sep;159(9):1514-20
pubmed: 12202271
Psychiatry Res. 2019 Mar;273:296-302
pubmed: 30677717
Biol Psychiatry. 2013 Dec 1;74(11):845-52
pubmed: 23954109
Br J Psychiatry. 2007 Sep;191:229-33
pubmed: 17766763
Schizophr Res. 2012 May;137(1-3):20-5
pubmed: 22365148
J Child Adolesc Ment Health. 2015;27(3):215-25
pubmed: 26890402
World Psychiatry. 2018 Feb;17(1):49-66
pubmed: 29352556
Psychiatry Clin Neurosci. 2017 Apr;71(4):247-253
pubmed: 27873466
Neuroimage. 2013 Jan 15;65:336-48
pubmed: 23041529
Schizophr Res. 2011 Aug;130(1-3):170-5
pubmed: 21620681
Schizophr Res. 2016 Aug;175(1-3):174-179
pubmed: 27107632
Psychol Med. 2015;45(12):2481-98
pubmed: 25903153
PLoS One. 2018 Dec 13;13(12):e0208779
pubmed: 30543649
Neuroimage. 2011 Jun 1;56(3):961-73
pubmed: 21315159