Significant changes of CD4, FOXP3, CD25, and IL6 expression level in Iranian COVID-19 patients.
COVID-19
Inflammatory responses
Interleukin 6
SARS-CoV-2
Treg
Journal
Gastroenterology and hepatology from bed to bench
ISSN: 2008-2258
Titre abrégé: Gastroenterol Hepatol Bed Bench
Pays: Iran
ID NLM: 101525875
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
27
11
2020
pubmed:
28
11
2020
medline:
28
11
2020
Statut:
ppublish
Résumé
Evaluating the expression level of CD4 COVID-19 is an emerging disease with worldwide distribution. However, there is a little data about the correlation between the disease and the host immune responses. Whole blood samples of 30 COVID-19 patients and eight healthy people were collected during March to June 2020. Total RNA was extracted from the samples, cDNA synthesis was performed, and the expression level of targeted genes was evaluated using quantitative real-time PCR. The expression level of CD4, CD25, and Foxp3 was significantly downregulated 5-, 2-, and 3-fold, respectively, among COVID-19 patients in comparison to healthy controls ( Our findings indicated the expression profile analysis of CD4
Sections du résumé
AIM
OBJECTIVE
Evaluating the expression level of CD4
BACKGROUND
BACKGROUND
COVID-19 is an emerging disease with worldwide distribution. However, there is a little data about the correlation between the disease and the host immune responses.
METHODS
METHODS
Whole blood samples of 30 COVID-19 patients and eight healthy people were collected during March to June 2020. Total RNA was extracted from the samples, cDNA synthesis was performed, and the expression level of targeted genes was evaluated using quantitative real-time PCR.
RESULTS
RESULTS
The expression level of CD4, CD25, and Foxp3 was significantly downregulated 5-, 2-, and 3-fold, respectively, among COVID-19 patients in comparison to healthy controls (
CONCLUSION
CONCLUSIONS
Our findings indicated the expression profile analysis of CD4
Types de publication
Journal Article
Langues
eng
Pagination
388-392Informations de copyright
©2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
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