METHOTREXATE TREATMENT FOR SARCOIDOSIS-INDUCED HYPERCALCEMIA.
Journal
AACE clinical case reports
ISSN: 2376-0605
Titre abrégé: AACE Clin Case Rep
Pays: United States
ID NLM: 101670593
Informations de publication
Date de publication:
Historique:
received:
01
03
2020
accepted:
13
07
2020
entrez:
27
11
2020
pubmed:
28
11
2020
medline:
28
11
2020
Statut:
epublish
Résumé
To present a patient with sarcoidosis-induced hypercalcemia who responded to methotrexate (MTX). The described case includes clinical and biochemical reports. A 65-year-old woman presented with bilateral hilar lymphadenopathy and pulmonary nodules. Her calcium and phosphorous levels were 11.4 mg/dL and 3.5 mg/dL, respectively. Blood levels of 25-hydroxyvitamin D and parathyroid hormone were 68 nmol/L and 23 pg/dL, respectively. A diagnosis of sarcoidosis was confirmed by a lymph node biopsy that revealed non-caseating granulomas. Prednisone therapy was efficacious in normalizing the calcium level. However, hypercalcemia recurred when the prednisone dosage was tapered to below15 mg daily. Following initiation of MTX at 15 mg/week, prednisone levels were successfully titrated to 3 mg daily. After a temporary withdrawal of MTX therapy, calcium levels increased dramatically to 17 mg/dL. MTX can be used as treatment for sarcoidosis-induced hypercalcemia.
Identifiants
pubmed: 33244491
doi: 10.4158/ACCR-2020-0120
pmc: PMC7685419
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e311-e314Informations de copyright
Copyright © 2020 AACE.
Déclaration de conflit d'intérêts
DISCLOSURE The authors have no multiplicity of interest to disclose.
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