Myopericytoma arising from myopericytosis-a hitherto unrecognized entity within the lung.
Adult
Aged, 80 and over
Angiogenesis Inhibitors
/ therapeutic use
Biomarkers, Tumor
/ analysis
Female
Humans
Lung
/ chemistry
Lung Neoplasms
/ chemistry
Myopericytoma
/ chemistry
Pericytes
/ chemistry
Precancerous Conditions
/ diagnostic imaging
Treatment Outcome
Vascular Endothelial Growth Factor Receptor-2
/ analysis
Vascular Endothelial Growth Factor Receptor-3
/ analysis
Lung
Myopericytoma
Myopericytosis
Pericytic tumor
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
18
08
2020
accepted:
15
11
2020
revised:
28
10
2020
pubmed:
28
11
2020
medline:
18
5
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Two cases of myopericytosis combined with pericytoma originating within the lung are reported. These are rare pulmonary tumors. The differential diagnosis for hemangiopericytoma and pericytic tumors with glomus elements is discussed. Both myopericytic lesions mimic other lesions, which are more commonly seen in the lung. Based on the expression of vascular growth factor receptors 2 and 3, an antiangiogenic therapy was suggested for the patient with the myopericytoma. A treatment with an angiogenesis inhibitor resulted in a regression of the tumor, but not the precursor lesion. Probably a more specific therapy using tyrosine kinase inhibitors for VEGFR2/3 might better control these myopericytic proliferations.
Identifiants
pubmed: 33244708
doi: 10.1007/s00428-020-02972-9
pii: 10.1007/s00428-020-02972-9
pmc: PMC8099806
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Biomarkers, Tumor
0
FLT4 protein, human
EC 2.7.10.1
KDR protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-3
EC 2.7.10.1
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
841-849Références
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