Safety of hydroxychloroquine for treatment or prevention of SARS-CoV-2 infection: A rapid systematic review and meta-analysis of randomized clinical trials.
COVID-19
SARS-CoV-2
hydroxychloroquine
meta-analysis
randomized controlled trials
safety
Journal
Immunity, inflammation and disease
ISSN: 2050-4527
Titre abrégé: Immun Inflamm Dis
Pays: England
ID NLM: 101635460
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
24
09
2020
revised:
26
10
2020
accepted:
28
10
2020
pubmed:
28
11
2020
medline:
12
2
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Hydroxycloroquine (HCQ) has been extensively studied for treatment and prevention of coronavirus diseases 2019 (COVID-19) from the start of the pandemic. Conflicting evidence about its usefulness has begun to accrue. In the face of controversial results about clinical efficacy of HCQ, we performed a rapid systematic review to assess its safety in the framework of COVID-19 randomized clinical trials. Five studies investigating 2291 subjects were included. The use of HCQ was associated with higher risk of adverse event compared with placebo or standard of care: odds ratio 4.57, 95% confidence interval 2.14-9.45. Safety profile of HCQ appears to be unsatisfactory when used to treat or prevent COVID-19, especially in the light of unproved clinical benefit.
Identifiants
pubmed: 33244901
doi: 10.1002/iid3.374
pmc: PMC7753686
doi:
Substances chimiques
Hydroxychloroquine
4QWG6N8QKH
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-36Informations de copyright
© 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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