Are different markers of endometrial receptivity telling us different things about endometrial function?


Journal

American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860

Informations de publication

Date de publication:
12 2020
Historique:
received: 04 05 2020
revised: 23 07 2020
accepted: 10 08 2020
pubmed: 28 11 2020
medline: 3 11 2021
entrez: 27 11 2020
Statut: ppublish

Résumé

To what extent do endocrine, immunological, gene expression and histological markers of endometrial receptivity correlate? Between November 2017 and September 2019, 121 women referred to a University Hospitals Fertility Clinic consented to inclusion in this cohort study. The women underwent timed endometrial biopsy followed by blood samples in a hormone-substituted cycle. Of these, 37 women had just started IVF treatment, and the remaining 84 had experienced recurrent implantation failure following IVF/ICSI. The hormone-substituted cycle consisted of initiation with oral oestradiol followed by addition of vaginal progesterone treatment for five full days. Endometrial biopsies were subject to histological examination, immune cell markers by immunohistochemistry (CD56 CD56 CD56

Identifiants

pubmed: 33245608
doi: 10.1111/aji.13323
doi:

Substances chimiques

Biomarkers 0
CD56 Antigen 0
Progesterone 4G7DS2Q64Y
Estradiol 4TI98Z838E

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13323

Informations de copyright

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Références

Rahmati M, Macklon N. Testing the endometrium: is there enough evidence to justify clinical use? Curr Opin Obs Gynecol. 2020;32(2):185-190.
Moffett A, Shreeve N. First do no harm: uterine natural killer (NK) cells in assisted reproduction. Hum Reprod. 2015;30(7):1519-1525.
Bulmer J, Morrison L, Longfellow M, Ritson A, Pace D. Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum Reprod. 1991;6(6):791-798.
Russell P, Sacks G, Tremellen K, Gee A. The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. III: Further observations and reference ranges. Pathology. 2013;45(4):393-401.
Wilkens J, Male V, Ghazal P, et al. Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil. J Immunol. 2013;191(5):2226-2235.
Druckmann R, Druckmann MA. Progesterone and the immunology of pregnancy. J Steroid Biochem Mol Biol. 2005;97(5):389-396.
Di Renzo GC, Giardina I, Clerici G, Brillo E, Gerli S. Progesterone in normal and pathological pregnancy. Horm Mol Biol Clin Investig. 2016;27(1):35-48.
Lash GE, Robson SC, Bulmer JN. Review: functional role of uterine natural killer (uNK) cells in human early pregnancy decidua. Placenta. 2010;31(SUPPL.):S87-S92.
Szekeres-Bartho J. The role of progesterone in feto-maternal immunological cross talk. Med Princ Pract. 2018;27(4):301-307.
Fukui A, Funamizu A, Yokota M, et al. Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia. J Reprod Immunol. 2011;90(1):105-110.
Tuckerman E, Mariee N, Prakash A, Li TC, Laird S. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol. 2010;87(1-2):60-66.
Lédée-Bataille N, Dubanchet S, Coulomb-L'hermine A, Durand-Gasselin I, Frydman R, Chaouat G. A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization. Fertil Steril. 2004;81(1):59-65.
Matteo M, Greco P, Rosenberg P, et al. Normal percentage of CD56bright natural killer cells in young patients with a history of repeated unexplained implantation failure after in vitro fertilization cycles. Fertil Steril. 2007;88(4):4-7.
Kofod L, Lindhard A, Bzorek M, Eriksen JO, Larsen LG, Hviid TVF. Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. Am J Reprod Immunol. 2017;78(3):e12684.
Fukui A, Fujii S, Yamaguchi E, Kimura H, Sato S, Saito Y. Natural killer cell subpopulations and cytotoxicity for infertile patients undergoing in vitro fertilization. Am J Reprod Immunol. 1999;41:413-422.
Kofod L, Lindhard A, Hviid TVF. Implications of uterine NK cells and regulatory T cells in the endometrium of infertile women. Hum Immunol. 2018;79:693-701.
Kuroda K, Venkatakrishnan R, James S, et al. Elevated periimplantation uterine natural killer cell density in human endometrium is associated with impaired corticosteroid signaling in decidualizing stromal cells. J Clin Endocrinol Metab. 2013;98:4429-4437.
Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Fertil Steril. 1950;1(1):3-25.
Murray MJ, Meyer WR, Zaino RJ, et al. A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril. 2004;81(5):1333-1343.
Diaz-Gimeno P, Horcajadas JA, Martinez-Conejero JA, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95(1):50-60.
Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, et al. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil Steril. 2013;100(3):818-824.
Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C. Profiling the gene signature of endometrial receptivity: clinical results. Fertil Steril. 2013;99(4):1078-1085.
Large MJ, Demayo FJ. The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling. Mol Cell Endocrinol. 2012;358:155-165.
Prapas Y, Prapas N, Jones EE, Duleba AJ, Olive DL, Chatziparasidou A. The window for embryo transfer in oocyte donation cycles depends on the duration of progesterone therapy. Hum Reprod. 1998;13(3):720-723.
Young SL, Savaris RF, Lessey BA, et al. Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod. 2017;32(9):1903-1914.
Ma W, Song H, Das SK, Paria BC, Dey SK. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci. 2003;100(5):2963-2968.
Simon C, Domı F, Valbuena D, Pellicer A. The role of estrogen in uterine receptivity and blastocyst implantation. TRENDS Endocrinol Metab. 2003;14(5):197-199.
Horcajadas JA, Mínguez P, Dopazo J, et al. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab. 2008;93(11):4500-4510.
Haouzi D, Assou S, Mahmoud K, Tondeur S, Re T. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod. 2009;24(6):1436-1445.
Giuliani E, Parkin KL, Lessey BA, Young SL, Fazleabas AT. Characterization of uterine NK cells in women with infertility or recurrent pregnancy loss and associated endometriosis. Am J Reprod Immunol. 2014;72(3):262-269.
Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, et al. The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity. Fertil Steril. 2013;99(2):508-517.
van der Linden M, Buckingham K, Farquhar C, Kremer J, Metwally M. Luteal phase support for assisted reproduction cycles ( Review ). Cochrane Database Syst Rev. 2015;7:1-267.
Alsbjerg B, Thomsen L, Elbaek HO, et al. Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes. Reprod Biomed Online. 2018;37(5):641-647.
Thomsen LH, Humaidan P, Erb K, Overgaard M, Andersen CY, Kesmodel US. Mid-Luteal 17-OH progesterone levels in 614 women undergoing IVF-treatment and fresh embryo transfer-daytime variation and impact on live birth rates. Front Endocrinol (Lausanne). 2018;9:1-13.
Labarta E, Mariani G, Holtmann N, Celada P, Remohí J, Bosch E. Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation : a prospective study. Hum Reprod. 2017;32(12):2437-2442.
Henderson TA, Saunders PTK, Moffett-King A, Groome NP, Critchley HOD. Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab. 2003;88(1):440-449.
Guo W, Li P, Zhao G, Fan H, Hu Y, Hou Y. Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells. Am J Reprod Immunol. 2012;67(6):463-473.
Mika KM, Li X, DeMayo FJ, Lynch VJ. An ancient fecundability-associated polymorphism creates a GATA2 binding site in a distal enhancer of HLA-F. Am J Hum Genet. 2018;103(4):509-521.
Yie SM, Xiao R, Librach CL. Progesterone regulates HLA-G gene expression through a novel progesterone response element. Hum Reprod. 2006;21(10):2538-2544.
Langkilde CH, Nilsson LL, Jørgensen N, et al. Variation in the HLA-F gene locus with functional impact is associated with pregnancy success and time-to-pregnancy after fertility treatment. Hum Reprod. 2020;35(3):705-717.
Fatemi H. Luteal phase after 3 decades of IVF : what do we know ? Reprod Biomed Online. 2009;19:1-13.
Kolibianakis E, Bourgain C, Albano C, et al. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002;78(5):1025-1029.
Lessey BA, Palomino WA, Apparao KBC, Young SL, Lininger RA. Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod Biol Endocrinol. 2006;10(4):1-10.
Dorostghoal M, Ghaffari H, Moramezi F, Keikhah N. Overexpression of endometrial estrogen receptor-alpha in the window of implantation in women with unexplained infertility. Int J Fertil Steril. 2018;12(1):37-42.
Lédée N, Petitbarat M, Chevrier L, et al. The uterine immune profile may help women with repeated unexplained embryo implantation failure after in vitro fertilization d e. Am J Reprod Immunol. 2016;75:388-401.

Auteurs

Malene Hviid Saxtorph (M)

Department of Gynaecology, Obstetrics, and Fertility, Zealand University Hospital, Roskilde, Denmark.
ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Department of Clinical Medicine, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Gry Persson (G)

ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology, Zealand University Hospital, Roskilde, Denmark.

Trine Hallager (T)

ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Department of Pathology, Zealand University Hospital, Roskilde, Denmark.

Kathrine Birch Petersen (K)

Department of Gynaecology, Obstetrics, and Fertility, Zealand University Hospital, Roskilde, Denmark.
ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Stork Fertility Clinic, VivaNeo/The Fertility Partnership, Roskilde, Denmark.

Jens O Eriksen (JO)

ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Department of Pathology, Zealand University Hospital, Roskilde, Denmark.

Lise Grupe Larsen (LG)

ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Department of Clinical Medicine, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Pathology, Zealand University Hospital, Roskilde, Denmark.

Nick Macklon (N)

Department of Gynaecology, Obstetrics, and Fertility, Zealand University Hospital, Roskilde, Denmark.
ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
London Womens Clinic, London, UK.

Thomas Vauvert F Hviid (TVF)

ReproHealth Research Consortium, Zealand University Hospital, Roskilde, Denmark.
Department of Clinical Medicine, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology, Zealand University Hospital, Roskilde, Denmark.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH