The first parent-child diagnosis of a multifocal squamous odontogenic tumor: A case report.
Case report
Multifocal SOT
Odontogenic
Parent-child relation
SOT
Squamous odontogenic tumor
Journal
Journal of stomatology, oral and maxillofacial surgery
ISSN: 2468-7855
Titre abrégé: J Stomatol Oral Maxillofac Surg
Pays: France
ID NLM: 101701089
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
08
10
2020
revised:
01
11
2020
accepted:
05
11
2020
pubmed:
28
11
2020
medline:
15
12
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Squamous odontogenic tumors (SOT) are rare, benign, odontogenic neoplasms of the jaws. The sporadically reported cases with multifocal SOTs seem to have a marked predilection for younger African American patients. In this case report a 14-year-old Caucasian male presented with swelling of the vestibular alveolar process, slight tooth divergence, and mobility. A multifocal squamous odontogenic tumor was diagnosed and subsequently treated twice with surgical enucleation. Two and a half years earlier his mother was diagnosed and treated for a similar multifocal SOT. Next-Generation-Sequencing targeted resequencing mutational analysis of the maternal surgical specimens was performed. No potential causal mutation could be identified. Postoperative follow-up of the patient showed no recurrence of the SOT after 2 years. This case report substantiates the possibility of a familial relationship in (multifocal) SOT, possibly changing current ideas concerning the etiology and treatment of these neoplasms.
Identifiants
pubmed: 33246182
pii: S2468-7855(20)30289-5
doi: 10.1016/j.jormas.2020.11.004
pii:
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
612-617Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.