Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities.
Anti-inflammatory
Anti-microbial
Aromatic nitro compounds
Catecholic alkaloid sulfonates
Portulaca oleracea
Portulacaceae
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
08
2020
revised:
03
11
2020
accepted:
07
11
2020
pubmed:
28
11
2020
medline:
19
12
2020
entrez:
27
11
2020
Statut:
ppublish
Résumé
Acidic compounds were enriched from a water decoction of Portulaca oleracea using 717 anion exchange resin column chromatography. A total of 22 compounds including 9 catecholamine derivatives, of which six were rare sulfonic acid derivatives, and 9 nitro derivatives, were further isolated through various column chromatographic methods, and their structures were elucidated by interpreting their spectroscopic data and ECD calculations. Among them, 16 compounds were isolated from P. oleracea for the first time, 8 of which were undescribed compounds and four compounds were natural products. Pharmacological screening indicated that cis-3-(3-nitro-4-hydroxyphenyl)-methyl acrylate exhibited anti-inflammatory activity, measured as inhibition of nitric oxide production in LPS-stimulated RAW264.7 macrophage cells, with an EC
Identifiants
pubmed: 33246306
pii: S0031-9422(20)31202-4
doi: 10.1016/j.phytochem.2020.112587
pii:
doi:
Substances chimiques
Alkaloids
0
Anti-Inflammatory Agents
0
Nitro Compounds
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112587Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.