NF-κB and Extrinsic Cell Death Pathways - Entwined Do-or-Die Decisions for T cells.
T cells
apoptosis
necroptosis
nuclear factor κB
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
06
08
2020
revised:
09
10
2020
accepted:
27
10
2020
pubmed:
29
11
2020
medline:
18
3
2021
entrez:
28
11
2020
Statut:
ppublish
Résumé
NF-κB signaling is required at multiple stages of T cell development and function. The NF-κB pathway integrates signals from many receptors and involves diverse adapters and kinases. Recent advances demonstrate that kinases controlling NF-κB activation, such as the IKK complex, serve dual independent functions because they also control cell death checkpoints. Survival functions previously attributed to NF-κB are in fact mediated by these upstream kinases by novel mechanisms. This new understanding has led to a refined view of how NF-κB and cell death signaling are interlinked and how they regulate cell fate. We discuss how NF-κB activation and control of cell death signaling by common upstream triggers cooperate to regulate different aspects of T cell development and function.
Identifiants
pubmed: 33246882
pii: S1471-4906(20)30257-X
doi: 10.1016/j.it.2020.10.013
pii:
doi:
Substances chimiques
NF-kappa B
0
I-kappa B Kinase
EC 2.7.11.10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
76-88Subventions
Organisme : Medical Research Council
ID : MR/P011225/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.